Results 111 to 120 of about 964 (143)
Rational Design in Photopharmacology With Molecular Photoswitches [PDF]
Angewandte Chemie - International Edition, 2023 AbstractPhotopharmacology is an attractive approach for achieving targeted drug action with the use of light. In photopharmacology, molecular photoswitches are introduced into the structure of biologically active small molecules to allow for the optical control of their potency.
Frank J Dekker +2 more
exaly +6 more sources
Emerging Targets in Photopharmacology [PDF]
Angewandte Chemie - International Edition, 2016 Abstract The field of photopharmacology uses molecular photoswitches to establish control over the action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of resistance, while achieving unprecedented precision in treatment.
Gooitzen M van Dam +2 more
exaly +6 more sources
Photopharmacology of Antimitotic Agents [PDF]
International Journal of Molecular Sciences, 2022 Antimitotic agents such as the clinically approved vinca alkaloids, taxanes and epothilone can arrest cell growth during interphase and are therefore among the most important drugs available for treating cancer. These agents suppress microtubule dynamics and thus interfere with intracellular transport, inhibit cell proliferation and promote cell death.
Zbigniew L Pianowski, Susanne Kirchner
exaly +6 more sources
Molecular and Cellular Endocrinology, 2019 New technologies for spatial and temporal remote control of G protein-coupled receptors (GPCRs) are necessary to unravel the complexity of GPCR signalling in cells, tissues and living organisms. An effective approach, recently developed, consists on the design of light-operated ligands whereby light-dependent GPCR activity regulation can be achieved ...
Joan Font, Amadeu Llebaria
exaly +5 more sources
Photopharmacology of G -Protein-Coupled Receptors
, 2022 G-protein-coupled receptors (GPCRs) are a super-family of membrane proteins and major targets for drug development. However, many GPCRs drug candidates suffer from a lack of selectivity. Photopharmacology gives the possibility of modulating GPCR activity
Xavier Gómez-Santacana +2 more
exaly +2 more sources
Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers [PDF]
Angewandte Chemie - International Edition, 2019 Photopharmacology relies on ligands that change their pharmacodynamics upon photoisomerization. Many of these ligands are azobenzenes that are thermodynamically more stable in their elongated transconfiguration, which predominates in the dark.
Bryan S Matsuura +2 more
exaly +4 more sources
Introduction: Optogenetics and Photopharmacology [PDF]
Chemical Reviews, 2018 Ernst Bamberg +2 more
exaly +3 more sources
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A Roadmap to Success in Photopharmacology
Accounts of Chemical Research, 2015Light is a fascinating phenomenon that ties together physics, chemistry, and biology. It is unmatched in its ability to confer information with temporal and spatial precision and has been used to map objects on the scale of tens of nanometers (10(-8) m) to light years (10(16) m).
Johannes, Broichhagen +2 more
openaire +2 more sources
Chemical Reviews, 2018
Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. As the photophysical, pharmacodynamic, and pharmacokinetic properties of photoswitches, such as azobenzenes, have ...
Katharina Hüll +2 more
openaire +2 more sources
Synthetic photoswitches have been known for many years, but their usefulness in biology, pharmacology, and medicine has only recently been systematically explored. Over the past decade photopharmacology has grown into a vibrant field. As the photophysical, pharmacodynamic, and pharmacokinetic properties of photoswitches, such as azobenzenes, have ...
Katharina Hüll +2 more
openaire +2 more sources
Photopharmacological control of lipid function
2020Photopharmacology enables the optical control of biological processes through the use of molecular photoswitches, such as functionalized azobenzenes. In this protocol, we describe general considerations for working with bioactive azobenzene photoswitches. Our approach is exemplified with a photoswitchable sphingosine-1-phosphate analog (PhotoS1P).
Johannes, Morstein, Dirk, Trauner
openaire +2 more sources