Results 41 to 50 of about 964 (143)

Light-Control over Casein Kinase 1δ Activity with Photopharmacology: A Clear Case for Arylazopyrazole-Based Inhibitors [PDF]

, 2022
Protein kinases are responsible for healthy cellular processes and signalling pathways, and their dysfunction is the basis of many pathologies. There are numerous small molecule inhibitors of protein kinases that systemically regulate dysfunctional ...
Vidya Sundaram, Sundaram, Vidya, Ben L. Feringa, Ashutosh Srivastava, Kolarski, Dušan, Feringa, Ben L., Wiktor Szymanski, Schulte, Albert M.; id_orcid, Dušan Kolarski, Albert M. Schulte, Szymanski, Wiktor, Florence Tama, Schulte, Albert M., Srivastava, Ashutosh, Tama, Florence   +14 more
core   +1 more source

Recent Approaches to the Identification of Novel Microtubule-Targeting Agents

Frontiers in Molecular Biosciences, 2022
Microtubules are key components of the eukaryotic cytoskeleton with essential roles in cell division, intercellular transport, cell morphology, motility, and signal transduction.
Susanna Eli, Rossella Castagna, Marina Mapelli, Emilio Parisini   +3 more
doaj   +1 more source

Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio

Bioscience Reports, 2015
Insulinomas cause neuroglycopenic symptoms, permanent neurological damage and even death. Current available therapies cannot satisfactorily treat malignant insulinomas and some benign insulinomas.
Jingwen Yi, Xiaoguang Yang, Lihua Zheng, Guang Yang, Luguo Sun, Yongli Bao, Yin Wu, Yanxin Huang, Chunlei Yu, Shao‑Nian Yang, Yuxin Li   +10 more
doaj   +1 more source

Orthogonal Control of Neuronal Circuits and Behavior Using Photopharmacology

, 2022
Over the last decades, photopharmacology has gone far beyond its proof-of-concept stage to become a bona fide approach to study neural systems in vivo.
Kolarski D., Durand-de Cuttoli R., Maleeva G., Castagna R., Galyna Maleeva, Dušan Kolarski, Romain Durand-de Cuttoli, Rossella Castagna   +7 more
core   +1 more source

Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos

Beilstein Journal of Organic Chemistry, 2020
This study evaluates the embryotoxicity of dithienylethene-modified peptides upon photoswitching, using 19 analogues based on the β-hairpin scaffold of the natural membranolytic peptide gramicidin S.
Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe Strähle, Igor V. Komarov, Anne S. Ulrich   +7 more
doaj   +1 more source

Photopharmacology: A new paradigm for vision restoration

Clinical and Translational Medicine
Robert J. Casson
doaj   +3 more sources

Photopharmacological Tools for Mitotic Cell Division

YAKUGAKU ZASSHI, 2022
Genetic information is replicated and transmitted from a parent cell to two identical daughter cells through mitotic cell division. To accomplish this dynamic process with high accuracy and precision, various motor proteins work in a concerted manner.
openaire   +2 more sources

Near Infrared Photoswitching by Direct Excitation—A Next Frontier

Angewandte Chemie International Edition, EarlyView.
Molecular photoswitches finally enter the spectral realm of near‐infrared for their direct excitation. This minireview summarizes the current state‐of‐the‐art, the design principles for achieving such low‐energy light responsiveness, and the unique applications that are unlocked by it.
Diptiprava Sahoo, Elias Ciekalski, Henry Dube   +2 more
wiley   +1 more source

Reversible Regulation of Succinate Dehydrogenase by Tools of Photopharmacology

, 2022
Succinate dehydrogenase (SDH) is extremely important in metabolic function and biological processes. Modulation of SDH has been reported to be a promising therapeutic target to SDH mutations.
Zhongli Shao, Yang Zhang (30734), Xusheng Shao, Cong Zhou, Jiagao Cheng (1409242), Wen Fu (2040040), Zhongli Shao (11846561), Jiagao Cheng, Zhiping Xu, Xusheng Shao (537212), Xujuan Sun (8757207), Zhiping Xu (654842), Yang Zhang, Wen Fu, Cong Zhou (62278), Zhong Li, Zhong Li (324520), Xujuan Sun   +17 more
core   +2 more sources

Reducing the Formation of Toxic Byproducts During the Photochemical Release of Epinephrine

Journal of Xenobiotics
Engineered light-sensitive molecules offer a sophisticated toolkit for the manipulation of biological systems with both spatial and temporal precision.
Mikhail A. Panfilov, Ezhena S. Starodubtseva, Tatyana Yu. Karogodina, Alexey Yu. Vorob’ev, Alexander E. Moskalensky   +4 more
doaj   +1 more source