Results 21 to 30 of about 964 (143)

Controlling drug activity with light:developments in photopharmacology [PDF]

, 2023
For millennia, humanity has been fascinated by the prospect of using visible light in medical applications. Nowadays, light is used in the clinic for intraoperative imaging and photodynamic therapy, among others.
Welleman, Ilse M., Szymanski, Wiktor
core   +4 more sources

Photopharmacology: Beyond Proof of Principle [PDF]

Journal of the American Chemical Society, 2014
Pharmacotherapy is often severely hindered by issues related to poor drug selectivity, including side effects, environmental toxicity, and the emergence of resistance. Lack of selectivity is caused by the inability to control drug activity in time and space.
Willem A. Velema, Wiktor Szymanski, and Ben L. Feringa   +2 more
openaire   +2 more sources

Photopharmacology for vision restoration

Current Opinion in Pharmacology, 2022
Blinding diseases that are caused by degeneration of rod and cone photoreceptor cells often spare the rest of the retinal circuit, from bipolar cells, which are directly innervated by photoreceptor cells, to the output ganglion cells that project axons to the brain.
Michael H, Berry, Amy, Holt, Johannes, Broichhagen, Prashant, Donthamsetti, John G, Flannery, Ehud Y, Isacoff   +5 more
openaire   +2 more sources

Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography

Nature Communications, 2023
Photopharmacology manipulates the biological activity of small molecules by light. Using an X-ray laser, the authors follow the release of the drug azo-combretastatin A4 from tubulin and the concomitant structural changes over nine orders of magnitude in
Maximilian Wranik, Tobias Weinert, Chavdar Slavov, Tiziana Masini, Antonia Furrer, Natacha Gaillard, Dario Gioia, Marco Ferrarotti, Daniel James, Hannah Glover, Melissa Carrillo, Demet Kekilli, Robin Stipp, Petr Skopintsev, Steffen Brünle, Tobias Mühlethaler, John Beale, Dardan Gashi, Karol Nass, Dmitry Ozerov, Philip J. M. Johnson, Claudio Cirelli, Camila Bacellar, Markus Braun, Meitian Wang, Florian Dworkowski, Chris Milne, Andrea Cavalli, Josef Wachtveitl, Michel O. Steinmetz, Jörg Standfuss   +30 more
doaj   +1 more source

Synthesis and Study of Dibenzo[b, f]oxepine Combined with Fluoroazobenzenes—New Photoswitches for Application in Biological Systems

Molecules, 2022
Dibenzo[b, f]oxepine derivatives are an important scaffold in natural, medicinal chemistry, and these derivatives occur in several medicinally relevant plants.
Filip Borys, Piotr Tobiasz, Jakub Sobel, Hanna Krawczyk   +3 more
doaj   +1 more source

Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue [PDF]

, 2021
Photopharmacology addresses the challenge of drug selectivity and side effects through creation of photoresponsive molecules activated with light with high spatiotemporal precision.
Feringa, B.L., Guskov, Albert, Marin, Egor, Hoorens, Mark, Poelarends, Gerrit; id_orcid, Guskov, Albert; id_orcid, Feringa, Ben L., Trinco, Gianluca, Hoorens, Mark W. H., Lameijer, Lucien N., Arkhipova, Valentina, Fu, Haigen, Slotboom, Dirk J., Lameijer, Lucien, Slotboom, Dirk, Poelarends, Gerrit J., Szymanski, Wiktor, Gianluca Trinco, Ben L. Feringa, Albert Guskov, Gerrit J. Poelarends, Valentina Arkhipova, Egor Marin, Haigen Fu, Wiktor Szymanski, Dirk J. Slotboom, Lucien N. Lameijer, Mark W. H. Hoorens   +27 more
core   +1 more source

In vivo photopharmacology for investigating the effect of opioid signaling on neural circuits [PDF]

, 2022
Understanding the neural circuitry of the opioid system in the brain is a pressing clinical and scientific problem. Endogenous opioids are implicated in myriad behavioral functions including reward and analgesia. In a clinical setting, widely used opioid
McClain, Shannan Page
core   +1 more source

Comparative EPR Study on the Scavenging Effect of Methotrexate with the Isomers of Its Photoswitchable Derivative

Pharmaceuticals, 2021
The scavenging effect of the antimetabolite dihydrofolate reductase inhibitor methotrexate (MTX) and the isomers of its photoswitchable derivate, cis- and trans-phototrexate (PHX), have been compared by ESR spectroscopy, with the application of a cyclic ...
Zsolt Preisz, Nóra Hartvig, Balázs Bognár, Tamás Kálai, Sándor Kunsági-Máté   +4 more
doaj   +1 more source

In vivo photopharmacology enabled by multifunctional fibers [PDF]

ACS Chemical Neuroscience, 2020
ABSTRACT To reversibly manipulate neural circuits with increased spatial and temporal control, photoswitchable ligands can add an optical switch to a target receptor or signaling cascade. This approach, termed photopharmacology, has been enabling to molecular neuroscience, however, its application to behavioral ...
James A. Frank, Marc-Joseph Antonini, Po-Han Chiang, Andres Canales, David B. Konrad, Indie C. Garwood, Gabriela Rajic, Florian Koehler, Yoel Fink, Polina Anikeeva   +9 more
openaire   +2 more sources

On the promise of photopharmacology using photoswitches: a medicinal chemist's perspective. [PDF]

, 2020
Photopharmacology is a growing area of endeavor that employs photoswitchable ligands to allow for light-dependent pharmacological activity. By coupling light to therapeutic action, improved spatial and temporal selectivity can be achieved and ...
Fuchter, Matthew J, Matthew J. Fuchter
core   +1 more source