Results 11 to 20 of about 964 (143)
Biaryl sulfonamides as cisoid azosteres for photopharmacology [PDF]
Chemical Communications, 2021 Biaryl sulfonamides are excellent candidates for the azologization approach that yields photoswitchable drugs more active in their metastable cis state, compared to the stable trans state.
Piermichele Kobauri +7 more
openaire +4 more sources
In vivo photopharmacology with light-activated opioid drugs [PDF]
Neuron, 2023 Traditional methods for site-specific drug delivery in the brain are slow, invasive, and difficult to interface with recordings of neural activity. Here, we demonstrate the feasibility and experimental advantages of in vivo photopharmacology using "caged" opioid drugs that are activated in the brain with light after systemic administration in an ...
Shannan P. McClain +17 more
openaire +5 more sources
Rational drug design in photopharmacology [PDF]
, 2022 Photopharmacology uses light to regulate the biological activity of drugs. This precise control is obtained through the incorporation of molecular photoswitches into bioactive molecules. A major challenge for photopharmacology is the rational design of photoswitchable drugs that show light-induced activation. Computer-aided drug design is an attractive
Kobauri, Piermichele; id_orcid +2 more
openaire +3 more sources
Remote control of glucose homeostasis in vivo using photopharmacology [PDF]
Scientific Reports, 2017 Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects.
Zenobia B. Mehta +9 more
doaj +2 more sources
Introduction to photoswitches and photopharmacology
Organic & Biomolecular ChemistryMartina Cacciarini, G. Andrew Woolley, Wiktor Szymanski and Nadja A. Simeth introduce the Organic & Biomolecular Chemistry and RSC Medicinal Chemistry cross-journal themed collection on ‘Photoswitches and Photopharmacology’.
Martina Cacciarini +3 more
openaire +6 more sources
Design of antibacterial molecules by photopharmacology (ECOPHOTOSKIN)
, 2023 Antibiotics are rejected in the environment after their use for treating human and animal bacterial infections. These residues are poorly eliminated by the actual wastewater treatment processes, impacting both animal, human and environmental health. This led to the emergence of antibiotic resistance in bacterial pathogens. To fight this issue, the last
Aubert, Amélie +4 more
openaire +3 more sources
Optogenetics and photopharmacology in pain research and therapeutics [PDF]
STEMedicine, 2020 Pain afflicts billions of people worldwide, who suffer especially from long-term chronic pain. This gruelling condition affects the nervous system at all levels: from the brain to the spinal cord, the Dorsal Root Ganglia (DRG) and the peripheral fibres ...
Federico Iseppon, Manuel Arcangeletti
doaj +3 more sources
Photopharmacology and photoresponsive drug delivery
Chemical Society ReviewsThis review outlines the applications of photopharmacology and photoresponsive drug delivery in controlling biological activities using light for diverse biomedical applications.
Yuwei Liu, Tianyi Wang, Weiping Wang
openaire +3 more sources
A fine-tuned azobenzene for enhanced photopharmacology in vivo
Cell Chemical Biology, 2021 Despite the power of photopharmacology for interrogating signaling proteins, many photopharmacological systems are limited by their efficiency, speed, or spectral properties. Here, we screen a library of azobenzene photoswitches and identify a urea-substituted "azobenzene-400" core that offers bistable switching between cis and trans with improved ...
Vanessa A. Gutzeit +12 more
openaire +4 more sources
Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors [PDF]
, 2022 Photopharmacology uses light to regulate the biological activity of drugs. This precise control is obtained through the incorporation of molecular photoswitches into bioactive molecules.
Nadja A. Simeth (4859923) +9 more
core +4 more sources