Results 11 to 20 of about 2,002 (201)
, 2014 Veel problemen die gerelateerd zijn aan geneesmiddelen, zoals bijwerkingen en resistentie, worden veroorzaakt doordat medicijnen altijd actief zijn: geneesmiddelen zijn actief in het hele lichaam waardoor bijwerkingen optreden en ze zijn zelfs nog actief in het milieu waardoor bacteriële resistentie kan ontstaan.
Velema, Wim
core +7 more sources
Remote control of glucose homeostasis in vivo using photopharmacology [PDF]
Scientific Reports, 2017 Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects.
Zenobia B. Mehta +9 more
doaj +3 more sources
Rational drug design in photopharmacology [PDF]
, 2022 Photopharmacology uses light to regulate the biological activity of drugs. This precise control is obtained through the incorporation of molecular photoswitches into bioactive molecules. A major challenge for photopharmacology is the rational design of photoswitchable drugs that show light-induced activation. Computer-aided drug design is an attractive
Kobauri, Piermichele
openaire +5 more sources
Photopharmacology beyond azobenzene photoswitches
Responsive MaterialsPhotopharmacology harnesses photoswitchable molecules to reversibly and precisely modulate biological activities, offering exceptional spatial and temporal control through non‐invasive illumination.
Huichao Guo +5 more
doaj +2 more sources
Optical Control of Adenosine A3 Receptor Signaling: Towards a Multimodal Phototherapy in Psoriasis? [PDF]
Frontiers in Immunology, 2022 Psoriasis is a long-lasting inflammatory disease primarily characterized by cutaneous and systemic manifestations but also showing multiple comorbidities (i.e., psoriatic arthritis, cardiometabolic diseases, psychological illnesses, inflammatory bowel ...
Francisco Ciruela +2 more
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Nanomaterials, 2023 Photopharmacology is a booming research area requiring a new generation of agents possessing simultaneous functions of photoswitching and pharmacophore.
Gulia Bikbaeva +9 more
doaj +1 more source
Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina
Pharmaceutics, 2022 Photopharmacological compounds such as azobenzene-based photoswitches have been shown to control the conductivity of ionic channels in a light-dependent manner and are considered a potential strategy to restore vision in patients with end-stage ...
Sergei Nikonov +9 more
doaj +1 more source
Photopharmacology for vision restoration
Current Opinion in Pharmacology, 2022 Blinding diseases that are caused by degeneration of rod and cone photoreceptor cells often spare the rest of the retinal circuit, from bipolar cells, which are directly innervated by photoreceptor cells, to the output ganglion cells that project axons to the brain.
Michael H, Berry +5 more
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Photopharmacology: Beyond Proof of Principle [PDF]
Journal of the American Chemical Society, 2014 Pharmacotherapy is often severely hindered by issues related to poor drug selectivity, including side effects, environmental toxicity, and the emergence of resistance. Lack of selectivity is caused by the inability to control drug activity in time and space.
Willem A. Velema +2 more
openaire +2 more sources
Molecules, 2023 The multitarget therapeutic strategy, as opposed to the more traditional ‘one disease-one target-one drug’, may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer’s disease (AD) and related dementias.
Marco Paolino +11 more
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