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Advanced Healthcare Materials
AbstractThe Golgi apparatus (GA) is central in shuttling proteins from the endoplasmic reticulum to different cellular areas. Therefore, targeting the GA to precisely destroy its proteins through local heat could induce apoptosis, offering a potential avenue for effective cancer therapy.
Mingwan Shi +6 more
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AbstractThe Golgi apparatus (GA) is central in shuttling proteins from the endoplasmic reticulum to different cellular areas. Therefore, targeting the GA to precisely destroy its proteins through local heat could induce apoptosis, offering a potential avenue for effective cancer therapy.
Mingwan Shi +6 more
openaire +2 more sources
Molecular Pharmaceutics
Photothermal therapy (PTT) is an effective cancer treatment method. Due to its easy focusing and tunability of the irradiation light, direct and accurate local treatment can be performed in a noninvasive manner by PTT. This treatment strategy requires the use of photothermal agents to convert light energy into heat energy, thereby achieving local ...
Siyi Yuan +7 more
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Photothermal therapy (PTT) is an effective cancer treatment method. Due to its easy focusing and tunability of the irradiation light, direct and accurate local treatment can be performed in a noninvasive manner by PTT. This treatment strategy requires the use of photothermal agents to convert light energy into heat energy, thereby achieving local ...
Siyi Yuan +7 more
openaire +2 more sources
Biomacromolecules
Photothermal therapy (PTT) is impeded by limited light penetration depth and cellular heat resistance induced by overexpressed heat shock proteins. Herein, we propose a ferrocene (Fc)-based supramolecular photothermal agent (PTA) to improve the therapeutic efficacy.
Jing Qian +5 more
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Photothermal therapy (PTT) is impeded by limited light penetration depth and cellular heat resistance induced by overexpressed heat shock proteins. Herein, we propose a ferrocene (Fc)-based supramolecular photothermal agent (PTA) to improve the therapeutic efficacy.
Jing Qian +5 more
openaire +2 more sources
Macromolecular Bioscience
AbstractPhotothermal disinfection is an emerging and efficient therapeutic method for treating various infections. However, the therapeutic efficacy is hindered by the poor tissue penetration of light. While tissue optical clearance technology can enhance light transmission, the stratum corneum impedes the delivery of clearing agents to deeper tissues.
Yiyan Cheng +4 more
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AbstractPhotothermal disinfection is an emerging and efficient therapeutic method for treating various infections. However, the therapeutic efficacy is hindered by the poor tissue penetration of light. While tissue optical clearance technology can enhance light transmission, the stratum corneum impedes the delivery of clearing agents to deeper tissues.
Yiyan Cheng +4 more
openaire +2 more sources
A BRD4-Targeting Photothermal Agent for Controlled Protein Degradation
Angewandte Chemie - International EditionAbstractBRD4 protein plays a pivotal role in cell cycle regulation and differentiation. Disrupting the activity of BRD4 has emerged as a promising strategy for inhibiting the growth and proliferation of cancer cells. Herein, we introduced a BRD4‐targeting photothermal agent for controlled protein degradation, aiming to enhance low‐temperature ...
Xiaohan Liu, Na Li, Kaiye Wang
exaly +3 more sources