Results 51 to 60 of about 17,235 (261)

EXPERIMENTAL TESTING OF AN IN VIVO METHOD OF PHOTOTOXICITY EVALUATION

Регуляторные исследования и экспертиза лекарственных средств, 2018
At present all new medicinal products and cosmetics that absorb medium-wavelength UVB, long-wavelength UVA, or visible light in the range 290–700 nm need to be tested for potential phototoxicity.
V. А. Vavilova, E. V. Shekunova, V. A. Kashkin, M. N. Makarova, V. G. Makarov, A. Ya. Khaymenov   +5 more
doaj   +1 more source

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

Advanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi, Pere Català, Gabriel Größbacher, Paulina Nuñez Bernal, Olaf Nijssen, Sammy Florczak, Wilco Nijenhuis, Nuria Crusellas‐Villorbina, Bram Nijhoff, Paul Delrot, Jos Malda, Andreas Hierholzer, Martin Fussenegger, Lukas C. Kapitein, Riccardo Levato   +14 more
wiley   +1 more source

Mitochondria Targeting with Luminescent Rhenium(I) Complexes

Molecules, 2017
Two new neutral fac-[Re(CO)3(phen)L] compounds (1,2), with phen = 1,10-phenanthroline and L = O2C(CH2)5CH3 or O2C(CH2)4C≡CH, were synthetized in one-pot procedures from fac-[Re(CO)3(phen)Cl] and the corresponding carboxylic acids, and were fully ...
Joanna Skiba, Tytus Bernaś, Damian Trzybiński, Krzysztof Woźniak, Giarita Ferraro, Daniela Marasco, Antonello Merlino, Marsel Z. Shafikov, Rafał Czerwieniec, Konrad Kowalski   +9 more
doaj   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

Programming Light‐Driven Surface Topographies in Liquid Crystal Elastomers for Potential Biomedical Applications Through Combined Experiments and Simulations

Advanced Materials Technologies, EarlyView.
A combined experimental and simulation study of light‐responsive liquid crystal elastomer surfaces operating under physiological conditions is reported, demonstrating programmable and highly spatially controlled topography formation through bottom‐side photomask exposure. Our study establishes a foundation for dynamic, light‐responsive biosurfaces with
Ruth M. C. Verbroekken, Akhila Gottipati, Burcu Gumuscu, Ratna Kumar Annabattula, Albert P. H. J. Schenning   +4 more
wiley   +1 more source

Molecular Appendix Adjusted Architectural Propagations of Red‐Light Controlled Macroscopic Photoactuating Performances

Advanced Robotics Research, EarlyView.
Amphiphilic chloroazobenzenes, bearing different amino acids as end groups alanine, phenylalanine, and valine, exhibit excellent photoisomerizations. Varying structures of three amino acid groups participate in supramolecular formations and therefore photoinduced morphological transformations via adjusting intermolecular interactions. These interaction
Shuangshuang Meng, Ming‐Hin Chau, Takashi Kajitani, Franco King‐Chi Leung   +3 more
wiley   +1 more source

Development of Folic Acid-Conjugated and Methylene Blue-Adsorbed Au@TNA Nanoparticles for Enhanced Photodynamic Therapy of Bladder Cancer Cells

Nanomaterials, 2020
Photodynamic therapy (PDT) is a promising treatment for malignancy. However, the low molecular solubility of photosensitizers (PSs) with a low accumulation at borderline malignant potential lesions results in the tardy and ineffective management of ...
Che-Wei Hsu, Nai-Chi Cheng, Mei-Yi Liao, Ting-Yu Cheng, Yi-Chun Chiu   +4 more
doaj   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Mycorrhizal alfalfa and surfactant affect the uptake and dissipation of phenanthrene in soil

Plant, Soil and Environment, 2019
A greenhouse experiment was conducted to compare the effects of biosurfactant Rhamnopyranoside and chemical surfactant Triton X-100 on the uptake of phenanthrene by mycorrhizal alfalfa (Medicago sativa L.) and phenanthrene dissipation in soil ...
Naiying Wu, Yingqi Li, Qian Zhou, Xiaocheng Chai   +3 more
doaj   +1 more source