Results 81 to 90 of about 32,162 (236)

Evaluating quality of life tools in North American patients with erythropoietic protoporphyria and X-linked protoporphyria. [PDF]

, 2019
BackgroundErythropoietic protoporphyria (EPP) and X-linked Protoporphyria (XLP) are rare photodermatoses presenting with severe phototoxicity. Although anecdotally, providers who treat EPP patients acknowledge their life-altering effects, tools that ...
Anderson, Karl E, Balwani, Manisha, Bissell, D Montgomery, Bloomer, Joseph, Bonkovsky, Herbert L, Desnick, Robert J, Naik, Hetanshi, Overbey, Jessica R, Phillips, John D, Singal, Ashwani, Wang, Bruce   +10 more
core   +1 more source

Drug phototoxicity in mice

Acta Dermato-Venereologica, 1978
A series of agents with alleged photosensitizing properties has been studied in mice by a quantitative in vivo method for acute drug phototoxicity. The method, originally developed for phenothiazine studies, was found suitable for several drug groups with varying mechanism of action, such as tetracyclines, protoporphyrin and psoralens.
B, Ljunggren, H, Möller
openaire   +2 more sources

Characterization of Vemurafenib Phototoxicity in a Mouse Model [PDF]

, 2017
Vemurafenib is a first-in-class, small molecule B-Raf kinase inhibitor for the treatment of patients with unresectable or metastatic melanoma carrying the BRAFV600E mutation, commercially available since 2011.
Bauer, Daniel, Boudon, Stéphanie Marie, Odermatt, Alex, Plappert-Helbig, Ulla   +3 more
core  

ECVAM Technical Report on the Status of Alternative Methods for Cosmetics Testing (2008-2009) [PDF]

, 2010
The ECVAM technical report presents the progress made in the development and validation of alternative methods for the human health effects relevant to the Cosmetics Directive. It provides an update on the activities described by ECVAM in 2005 , 2006 and
BREMER Susanne, CASATI Silvia, CERIDONO MARA, COECKE Sandra, CORVI Raffaella, ESKES Chantra, KINSNER-OVASKAINEN Agnieszka, KREYSA JOACHIM, PELLIZZER Cristian, PRIETO PERAITA Maria Del Pilar, VIEGAS BARROSO JOAO FILIPE, WORTH Andrew, ZUANG Valerie   +12 more
core   +1 more source

Repeated exposure to low doses of light induces retinal damage in vivo in a wavelength-dependent manner

Ecotoxicology and Environmental Safety
The exposure of the general population to artificial light at night has dramatically increased in recent decades. Current standards for domestic lighting are based on acute exposure to light and consider blue wavelengths to be responsible for ...
Anaïs Françon, Laurent Jonet, Francine Behar-Cohen, Alicia Torriglia   +3 more
doaj  

Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis [PDF]

, 2009
This protocol describes imaging and computational tools to collect and analyze live imaging data of embryonic cell migration. Our five-step protocol requires a few weeks to move through embryo preparation and four-dimensional (4D) live imaging using ...
Fraser, Scott E., McMahon, Amy, Stathopoulos, Angelike, Supatto, Willy   +3 more
core   +2 more sources

Two Small Molecule Drugs with Topical Applications, Diflunisal and Naphazoline, and Their Potentially Toxic Photodegradants: Analysis by Chemical and Biological Methods

Molecules
Because of their topical application in patients and meaningful UV/VIS absorptive properties, the degradation and potential toxicity under irradiation of diflunisal (DIF) and naphazoline (NAF) were studied.
Karolina Lejwoda, Anna Gumieniczek, Agata Filip, Beata Naumczuk   +3 more
doaj   +1 more source

Snapshot 3D tracking of insulin granules in live cells

, 2018
Rapid and accurate volumetric imaging remains a challenge, yet has the potential to enhance understanding of cell function. We developed and used a multifocal microscope (MFM) for 3D snapshot imaging to allow 3D tracking of insulin granules labeled with ...
Alan Selewa, Hannah Yi, Itay Gdor, Mark Hereld, Matthew Daddysman, Norbert Scherer, Theresa Haunold, Xiang Huang, Xiaolei Wang   +8 more
core   +1 more source

Lysosome-associated miniSOG as a photosensitizer for mammalian cells

BioTechniques, 2016
Genetically encoded photosensitizers represent a promising optogenetic tool for the induction of light-controlled oxidative stress strictly localized to a selected intracellular compartment.
Alina P. Ryumina, Ekaterina O. Serebrovskaya, Dmitry B. Staroverov, Olga A. Zlobovskaya, Alexander S. Shcheglov, Sergey A. Lukyanov, Konstantin A. Lukyanov   +6 more
doaj   +1 more source

The blue light hazard and its use on the evaluation of photochemical risk for domestic lighting. An in vivo study

Environment International
Background: Nowadays artificial light highly increases human exposure to light leading to circadian rhythm and sleep perturbations. Moreover, excessive exposure of ocular structures to photons can induce irreversible retinal damage.
Anaïs Françon, Francine Behar-Cohen, Alicia Torriglia   +2 more
doaj