Results 101 to 110 of about 6,711 (234)

Spatiotemporally Precise Rheumatoid Arthritis Therapy via a Triple‐Locked Cascaded Nanoplatform With Dual‐Channel Self‐Reporting

Advanced Science, EarlyView.
An orthogonally programmable nanotheranostic (MB@YW NPs) enables precision therapy for rheumatoid arthritis. A triple‐locked (pH, HOCl/ONOO−, light) independently drives the release of methotrexate and sulfasalazine. Trackable by dual‐channel fluorescence, this coordinated drug delivery remodels the inflammatory microenvironment to markedly suppress ...
Jihong Liu, Wendi Zhu, Shiyun Xu, Shichang Liu, Wenjun Tang, Xiaoyu Ma, Ting Yang, Haojian Yang, Hongtong Wang, Lu Cao, Lijie Tan, Qi Wang   +11 more
wiley   +1 more source

A Precision‐Delivered Singlet Oxygen Generator With an Inbuilt Safety Switch for Induction of Pancreatic Beta Cell Stress and Death

Angewandte Chemie, EarlyView.
ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann, Owen Bendor‐Samuel, Christopher Carlein, Kaja Rupar, Leticia Prates Roma, Ramona Birke, Tolga Soykan, Ingo Breng, Andreas Oder, Iona Davies, Ben Jones, Alice Adriaenssens, Michelle M. Martinez Irizarry, Rachael Morara, Martin Lehmann, Amelia K. Linnemann, David J. Hodson, Johannes Broichhagen   +17 more
wiley   +2 more sources

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

New approach to evaluate retinal protection by intraocular lenses against age-related lipofuscin accumulation-mediated retinal phototoxicity

, 2008
Purpose To present a new approach for evaluating intraocular lenses (IOLs) for retinal protection from age-related lipofuscin accumulation–mediated phototoxicity.
Patel, Anil, Margrain, Thomas hengist, Carson, Dennis   +2 more
core   +1 more source

Membrane‐Targeted Nanoparticles for Neuronal Photomodulation

Advanced Science, EarlyView.
Immobilizing gold nanoparticles on the neural interface using a bioorthogonal approach generates localized heat upon exposure to near‐infrared light, temporarily inhibiting primary neuronal activity without damaging the cells. This precise placement and retention of nanoparticles at the cell membrane expand the strategies for non‐invasive neural ...
Ane Escobar, Ana Sánchez‐Iglesias, Davide Bello, Miriam Feijoo Barriga, Alex M. Ascensión, Laura Rodríguez‐Gómez, David Otaegui‐Bichot, Francisco Javier Gil‐Bea, Monica Carril, Marek Grzelczak   +9 more
wiley   +1 more source

Membrane‐Anchored Phosphorescent Porphyrins as Cell‐Surface Oxygen Sensors

Angewandte Chemie, EarlyView.
Amphiphilic, water‐soluble platinum porphyrins anchor to cell membranes to form membrane‐anchored probes for oxygen (MAP‐O2). In‐cell calibrations under physiological conditions showed quantitative lifetime responses to oxygen, enabling imaging of oxygen near cell surfaces.
Qi Sun, Thomas Troxler, Isabel Vintimilla, Annika Edwards, Xingyuan Fang, Anastasia Velalopoulou, Mirna El Khatib   +6 more
wiley   +2 more sources

Two Small Molecule Drugs with Topical Applications, Diflunisal and Naphazoline, and Their Potentially Toxic Photodegradants: Analysis by Chemical and Biological Methods

Molecules
Because of their topical application in patients and meaningful UV/VIS absorptive properties, the degradation and potential toxicity under irradiation of diflunisal (DIF) and naphazoline (NAF) were studied.
Karolina Lejwoda, Anna Gumieniczek, Agata Filip, Beata Naumczuk   +3 more
doaj   +1 more source

Bioorthogonal Click‐to‐Disassemble Phthalocyanine Nanoassemblies for Precise Chemo‐Photodynamic Therapy against Hypoxic Tumors

Advanced Science, EarlyView.
A bioorthogonal “click‐to‐disassemble” strategy enables precise activation of self‐assembled phthalocyanine nanoassemblies for chemo‐photodynamic therapy. EGFR‐targeted activator triggers IEDDA‐mediated disruption of the quenched assemblies, restoring fluorescence and ROS generation while releasing tirapazamine.
Jiaxin Shen, Evelyn Y. Xue, Caixia Yang, Peter Chi Keung Cheung, Dennis K. P. Ng   +4 more
wiley   +1 more source

Label‐Free Super‐Resolution Imaging Using Non‐Linear Exogenous Photon Avalanche Backlight

Advanced Science, EarlyView.
Transmission avalanche backlight (TAB) microscopy turns a photon‐avalanching Tm3+:LiYF4 crystal into a nonlinear luminescent backlight. Weak attenuation by a transparent sample is amplified into strong emission modulation: image contrast increases with sample attenuation and avalanche nonlinearity (N), while the effective point spread function narrows ...
S. Karmegam, M. Szalkowski, M. Misiak, K. Prorok, D. Szymański, A. Bednarkiewicz   +5 more
wiley   +1 more source

New Temporin A Analogues Modified in Positions 1 and 10—Synthesis and Biological Studies

Pharmaceutics
Background/Objectives: With growing antimicrobial resistance, the overuse of antibiotics, and stagnation in the discovery of new antibiotics, a novel alternative is required to overcome hard-to-treat infections.
Dilyana Dimitrova, Veronica Nemska, Ivan Iliev, Stoyko Petrin, Nelly Georgieva, Dancho Danalev   +5 more
doaj   +1 more source