Results 121 to 130 of about 2,726 (151)

A Model of the Rat Phrenic Motor Neuron

IEEE Transactions on Biomedical Engineering, 2002
We have developed a model for the rat phrenic motor neuron (PMN) that robustly replicates many experimentally observed behaviors of PMNs in response to pharmacological, ionic, and electrical perturbations using a single set of parameters. Our model suggests that the after-depolarization (ADP) response seen in action potentials is a result of the slow ...
Behrang Amini, Akhil Bidani, Joseph B. Zwischenberger, John W. Clark Jr.   +3 more
openaire   +2 more sources

Size-dependent differences in mitochondrial volume density in phrenic motor neurons

Journal of Applied Physiology, 2023
Type S and FR motor units, comprising smaller phrenic motor neurons (PhMNs) are regularly activated to perform indefatigable ventilatory requirements. By contrast, type FF motor units, comprising larger PhMNs, are infrequently activated to perform expulsive straining and airway defense maneuvers.
Matthew J. Fogarty, Sabhya Rana, Carlos B. Mantilla, Gary C. Sieck   +3 more
openaire   +2 more sources

Inactivity-induced phrenic motor facilitation requires PKCζ activity within phrenic motor neurons

Journal of Neurophysiology
We report important new findings concerning the mechanisms regulating a form of spinal neuroplasticity elicited by prolonged inhibition of respiratory neural activity, inactivity-induced phrenic motor facilitation (iPMF). We demonstrate that the atypical PKC isoform PKCζ within phrenic motor neurons is necessary for long-lasting iPMF, whereas ...
Nathan A. Baertsch, Alexandria B. Marciante, Gordon S. Mitchell, Tracy L. Baker   +3 more
openaire   +2 more sources

Intrapleural CTB‐saporin selectively kills phrenic motor neurons: a motor neuron disease model

The FASEB Journal, 2013
Amyotrophic lateral sclerosis (ALS) is a devastating disease leading to progressive motor neuron degeneration and ultimately, ventilatory failure. In a rodent model of ALS (SOD1 G93A rats), ventilatory capacity is preserved despite >;50% loss of phrenic and intercostal motor neurons (
Nicole Louise Nichols, Stephane Vinit, Gordon S Mitchell   +2 more
openaire   +1 more source

Phrenic motor neuron activation using temporal interference stimulation

The FASEB Journal, 2020
Based on deep brain stimulation data, we are using a method called temporal interference (T‐I) stimulation to activate phrenic motor neurons in adult rats. The premise is to target the deep ventral motor pools of the spinal cord with two high frequency but low amplitude electrical ...
Michael D. Sunshine, Antonino M. Cassarà, Esra M. Neufeld, Nir Grossman, Kevin J. Otto, Edward S. Boyden, David D. Fuller   +6 more
openaire   +1 more source

Postnatal Inhibition of TrkB Kinase Reduces the Number of Phrenic Motor Neurons

Physiology, 2023
During embryonic development, the number of phrenic motor neurons (PhMNs) declines precipitously during the final trimester and continues into the early postnatal period. When BDNF/TrkB signaling is absent in utero, animals do not survive after birth, most likely due to excessive loss of vital motor neurons (e.g., PhMNs).
Joline Brandenburg, Matthew Fogarty, Wen-Zhi Zhan, Gary Sieck   +3 more
openaire   +1 more source

Age‐Related Loss of Phrenic Motor Neurons: Reduced Myogenic Influence?

The FASEB Journal, 2020
There is an age‐associated loss of phrenic motor neurons (PhMNs) and withdrawal of pre‐synaptic terminals at neuromuscular junctions (NMJs) in 24‐month old Fischer 344 (F344) rats. Previously, we showed that age‐related PhMN loss is concomitant with neuromuscular transmission failure and diaphragm muscle (DIAm)
Ann M. Wilfred, Matthew J. Fogarty, Carlos B. Mantilla, Gary C. Sieck   +3 more
openaire   +1 more source

Size‐Dependence of Mitochondrial Density & Morphology in Phrenic Motor Neurons

The FASEB Journal, 2020
Neuromotor control of diaphragm muscle is dependent on the orderly recruitment of phrenic motor neurons (PhMNs) in a size‐dependent manner. Type S and FR motor units comprise smaller, more easily recruited PhMNs that innervate fatigue resistant, lower force‐producing type I and type IIa muscle fibers. Type FInt
Matthew J. Fogarty, Sabhya Rana, Carlos B. Mantilla, Gary C. Sieck   +3 more
openaire   +1 more source

Age-Related Loss of Phrenic Motor Neurons in Rats

Physiology
The diaphragm muscle (DIAm) is the major inspiratory muscle. Neural control of DIAm activation involves recruitment of phrenic motor neurons. Activation of the DIAm during breathing involes recruitment of fatigue resistant motor units comprising smaller PhMNs and type I and IIa muscle fibers. More force, but infrequent non-ventilatory behaviors of the
Aliyah Alabdulqadar, Matthew Fogarty, Debanjali Dasgupta, Carlos B. Mantilla, Gary C. Sieck   +4 more
openaire   +1 more source

Histological Analysis of Phrenic Motor Neurons Pompe Disease

Physiology
Pompe disease is a neuromuscular disorder resulting from mutations in the gene encoding acid α-glucosidase (GAA), an enzyme responsible for lysosomal glycogen degradation. Intravenous enzyme replacement therapy is the current standard of care but does not target the central nervous system (CNS).
Cabral Katelyn, Sabhya Rana, Megan Pope, Manuela Corti, Ramon Sun, Matthew Gentry, Barry Byrne, David Fuller   +7 more
openaire   +1 more source