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Phthalates: metabolism and exposure

International Journal of Andrology, 2007
Summary In human metabolism studies we found that after oral application of di(2‐ethylhexyl) phthalate (DEHP), diisononyl phthalate (DiNP) and di(2‐propylheptyl) phthalate (DPHP), at least 74, 44 and 34%, respectively, are excreted via urine. In contrast to the short chain phthalates, their oxidized products, not the simple monoesters, were found to be
Matthias, Wittassek, Jürgen, Angerer
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Phthalate Risks, Phthalate Regulation, and Public Health: A Review

Journal of Toxicology and Environmental Health, Part B, 2009
As a result of concerns about the toxicity of phthalates to humans, several expert panels were convened toward the end of the 1990s to evaluate the implications of the scientific evidence for the risks of phthalates to humans of all ages. These panels concluded that the risks were low although they had concerns about specific applications of some ...
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Rates of the Phthalate Dioxygenase Reaction with Oxygen Are Dramatically Increased by Interactions with Phthalate and Phthalate Oxygenase Reductase

Biochemistry, 2004
The phthalate dioxygenase system, which catalyzes the dihydroxylation of phthalate to form its cis-dihydrodiol (DHD), has two components: phthalate dioxygenase (PDO), a multimer with one Rieske-type [2Fe-2S] and one Fe(II) center per monomer, and phthalate dioxygenase reductase (PDR), which contains flavin mononucleotide (FMN) and a plant-like ...
Michael, Tarasev   +2 more
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Phthalates and Children’s Health

Current Problems in Pediatric and Adolescent Health Care, 2008
Phthalates are a class of man-made chemicals produced in large volumes and used in a wide variety of industrial and common household products such as children’s toys, lubricants, baby care products, chemical stabilizers in cosmetics, personal care products, medical products including intravenous (IV) tubing, and polyvinyl chloride (PVC) tubing.
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Phthalate monoesters as markers of phthalate contamination in wild marine organisms

Environmental Pollution, 2016
The level of phthalate esters (PAEs) alone is not considered to be a sufficient indicator of PAE pollution due to the quick metabolism of PAEs in the biota. The primary metabolites of PAEs, monoalkyl phthalate esters (MPEs), may also be an important indicator. However, PAE metabolism has scarcely been documented in wild marine organisms.
Xialin, Hu   +3 more
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Baby Products and Phthalates

Pediatrics, 2008
To the Editor .— The article by Sathyanarayana et al1 in the February 2008 issue of Pediatrics purported to show a link between the use of baby products (lotion, shampoo, and powder) and the presence of higher levels of phthalates in the urine of infants aged 2 to 28 months.
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Phthalates and uterine disorders

Reviews on Environmental Health
Abstract Humans are ubiquitously exposed to environmental endocrine disrupting chemicals such as phthalates. Phthalates can migrate out of products and enter the human body through ingestion, inhalation, or dermal application, can have potential estrogenic/antiestrogenic and/or androgenic/antiandrogenic activity, and are involved in many
Shuhong, Yang, Shuhao, Yang, Aiyue, Luo
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7 Final Report on the Safety Assessment of Dibutyl Phthalate, Dimethyl Phthalate, and Diethyl Phthalate

Journal of the American College of Toxicology, 1985
Dibutyl Phthalate (DBP), Dimethyl Phthalate (DMP), and Diethyl Phthalate (DEP) are dialkyl phthalates used primarily in cosmetics at concentrations of less than 10 percent as plasticizers, solvents, and perfume fixatives. These phthalates are rapidly absorbed, metabolized, and excreted. Acute animal feeding studies indicate that these ingredients are
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Phthalates, long‐chain (diisononyl phthalate, di‐n‐decyl phthalate, diisodecyl phthalate, diundecyl phthalate and didodecyl phthalate) : Air Monitoring Method

2016
Von Hahn, Nadja   +8 more
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Phthalates in sediments

Environmental Science & Technology, 1995
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