Results 101 to 110 of about 65,167 (186)
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley +3 more
wiley +1 more source
Excitation spectra for phycoerythrin and chlorophyll in the wild type and green mutant.
(A) Fluorescence emission at 340 nm. (B) Fluorescence emission at 480 nm. Phycoerythrin absorbs maximally around 580 nm, while Chlorophyll absorbs maximally around 680 nm.
Xiaoyun Huang (659874) +10 more
core +1 more source
Mixtures of Neural Network Experts With Application to Phytoplankton Flow Cytometry Data
ABSTRACT Flow cytometry is a valuable technique that measures the optical properties of particles at a single‐cell resolution. When deployed in the ocean, flow cytometry allows oceanographers to study different types of photosynthetic microbes called phytoplankton.
Ethan Pawl +3 more
wiley +1 more source
Schematic overview of NK‐EV isolation strategies from expanded primary human NK cells. Primary human NK cells were isolated from PBMCs and expanded using K562 feeder cells. EV‐containing preparations were then isolated from expanded NK‐cell cultures using two approaches. First, total exosome isolation reagent was used as a precipitation‐based method to
Huy Phuoc Quang Nguyen +9 more
wiley +1 more source
A new phycoerythrin, SCH-phycoerythrin, was purified from Synechococcus sp. ECS-18 by DEAE-Sephacel anion exchange chromatography and Sephacryl S-300 gel filtration.
Noh, Jae-Hoon +7 more
core +1 more source
Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo +3 more
wiley +1 more source
Abstract Drought is one of the most severe and complex natural hazards causing changes in water balance and impeding crucial water‐dependent ecosystem services. Over the last 25 years, multiple severe droughts linked to El Niño events have affected the Zambian and Zimbabwean regions.
Anna Joelle Greife +11 more
wiley +1 more source
Our study shows that microbial community diversity in Patagonian fjords varies with glacial influence and salinity, with a widespread bacterial core but a patchier eukaryotic core. Distinct co‐occurrence networks and marked short‐term community shifts occur in water‑ versus land‐terminating glacier fjords, underscoring meltwater influence in this ...
Nicole Trefault +5 more
wiley +1 more source
GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng +13 more
wiley +1 more source

