Results 101 to 110 of about 65,167 (186)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

open access: yesFEBS Open Bio, Volume 16, Issue 10, Page 1934-1943, October 2026.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara   +3 more
wiley   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3513-3526, October 2026.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley   +3 more
wiley   +1 more source

Excitation spectra for phycoerythrin and chlorophyll in the wild type and green mutant.

open access: yes, 2017
(A) Fluorescence emission at 340 nm. (B) Fluorescence emission at 480 nm. Phycoerythrin absorbs maximally around 580 nm, while Chlorophyll absorbs maximally around 680 nm.
Xiaoyun Huang (659874)   +10 more
core   +1 more source

Mixtures of Neural Network Experts With Application to Phytoplankton Flow Cytometry Data

open access: yesEnvironmetrics, Volume 37, Issue 7, October 2026.
ABSTRACT Flow cytometry is a valuable technique that measures the optical properties of particles at a single‐cell resolution. When deployed in the ocean, flow cytometry allows oceanographers to study different types of photosynthetic microbes called phytoplankton.
Ethan Pawl   +3 more
wiley   +1 more source

Natural Killer Cell‐Derived Extracellular Vesicle Preparations Demonstrate Potent Antitumor Activity Against Human Glioblastoma In Vitro and In Vivo

open access: yesJournal of Extracellular Biology, Volume 5, Issue 10, October 2026.
Schematic overview of NK‐EV isolation strategies from expanded primary human NK cells. Primary human NK cells were isolated from PBMCs and expanded using K562 feeder cells. EV‐containing preparations were then isolated from expanded NK‐cell cultures using two approaches. First, total exosome isolation reagent was used as a precipitation‐based method to
Huy Phuoc Quang Nguyen   +9 more
wiley   +1 more source

Isolation and characterization of a new phycoerythrin from the cyanobacterium Synechococcus sp. ECS-18

open access: yes, 2010
A new phycoerythrin, SCH-phycoerythrin, was purified from Synechococcus sp. ECS-18 by DEAE-Sephacel anion exchange chromatography and Sephacryl S-300 gel filtration.
Noh, Jae-Hoon   +7 more
core   +1 more source

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3‐Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia

open access: yesPhytotherapy Research, Volume 40, Issue 10, Page 5988-6004, October 2026.
Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo   +3 more
wiley   +1 more source

Effects of Reduced Precipitation and Water Level Variability on Phytoplankton Dynamics and Thermal Structure in a Large Tropical Reservoir

open access: yesWater Resources Research, Volume 62, Issue 10, October 2026.
Abstract Drought is one of the most severe and complex natural hazards causing changes in water balance and impeding crucial water‐dependent ecosystem services. Over the last 25 years, multiple severe droughts linked to El Niño events have affected the Zambian and Zimbabwean regions.
Anna Joelle Greife   +11 more
wiley   +1 more source

Stable Bacterial Cores and Patchy Eukaryotic Communities Shape the Summer Microbiomes of Patagonian Fjord Ecosystems Across Spatial, Functional and Temporal Gradients

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Our study shows that microbial community diversity in Patagonian fjords varies with glacial influence and salinity, with a widespread bacterial core but a patchier eukaryotic core. Distinct co‐occurrence networks and marked short‐term community shifts occur in water‑ versus land‐terminating glacier fjords, underscoring meltwater influence in this ...
Nicole Trefault   +5 more
wiley   +1 more source

uPAR‐Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non‐Human Primates With Serum Aminotransferase Activity as a Safety Monitor

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng   +13 more
wiley   +1 more source

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