Results 41 to 50 of about 65,167 (186)
Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency
Advanced Materials, EarlyView.As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang +12 more
wiley +1 more source
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source
Nitrogen-fixing cyanobacterium with a high phycoerythrin content [PDF]
, 1989 The elemental and molecular composition, pigment content, and productivity of a phycoerythrin-rich nitrogen-fixing cyanobacterium-an Anabaena strain isolated from the coastal lagoon Albufera de Valencia, Spain-has been investigated.
Losada Villasante, Manuel +3 more
core +1 more source
Advanced Science, EarlyView.Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai +16 more
wiley +1 more source
Molecules, 2021 Though numerous valuable compounds from red algae already experience high demand in medicine, nutrition, and different branches of industry, these organisms are still recognized as an underexploited resource.
Nikolay Yanshin +4 more
doaj +1 more source
Ciencias Marinas, 2002 The effects of different incident irradiances on growth, photosynthesis, pigment content and nutrient uptake were studied in dense cultures of the cryptophyte Rhodomonas salina (Wislouch) Hill y Wetherbee.
A Bartual +3 more
doaj +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Marine DrugsPhycobiliproteins (PBPs), captivating water-soluble proteins found in cyanobacteria, red algae, and cryptophytes, continue to fascinate researchers and industries due to their unique properties and multifaceted applications.
Celestino García-Gómez +12 more
doaj +1 more source
A Low-Cost, High-Performance System for Fluorescence Lateral Flow Assays
Biosensors, 2013 We demonstrate a fluorescence lateral flow system that has excellent sensitivity and wide dynamic range. The illumination system utilizes an LED, plastic lenses and plastic and colored glass filters for the excitation and emission light.
Linda G. Lee +3 more
doaj +1 more source
Studies on Extraction and Stability of C-Phycoerythrin From a Marine Cyanobacterium
Frontiers in Sustainable Food Systems, 2020 Being a naturally produced colorant with fluorescent properties, C-phycoerythrin (CPE) has important food industry applications. However, optimization of extraction and its stability under storage is an aspect which needs further attention. In this study,
Tonmoy Ghosh +3 more
doaj +1 more source