Results 191 to 200 of about 1,161,913 (308)

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Translation‐Promoting Effects of RNA Template Overhangs in the Absence of Ribosomes

Angewandte Chemie, EarlyView.
Ribosome‐free translation of an RNA sequence into a peptide sequence can be controlled by the folding of the template strand. Overhang sequences forming a triplex structure with the templating region and the peptidoyl RNA in pH‐dependent manner increase yields up to 40‐fold through entropic effects and mixed anhydride formation, allowing for controlled,
Nikolaos Giannakopoulos, Martin Rentschler, Clemens Richert   +2 more
wiley   +2 more sources

Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis

Animal Models and Experimental Medicine, EarlyView.
This study developed a biosafe, accessible, and versatile murine model of bone TB using Mycobacterium smegmatis, a fast‐growing, nonpathogenic mycobacterial species with high genomic homology to Mycobacterium tuberculosis. Three infection routes—subperiosteal calvarial injection, intratibial injection, and intracardiac (left ventricular) inoculation ...
Yewei Jia, Yuhuai Guo, Yusheng Yang, Jie Zhang, Ziyang Zhang, Ying Qu, Jiulin Tan, Jie Shen, Nathachit Limjunyawong, Jianzhong Xu, Zehua Zhang, Fei Luo, Ce Dou   +12 more
wiley   +1 more source

The complete mitochondrial genome of <i>Glischrochilus (Librodor) japonius</i> (Coleoptera: Nitidulidae). [PDF]

Mitochondrial DNA B Resour
Du H, Yang Z, Luo W, Gu J, Luo H, Di Y, Wang J, Shen J.   +7 more
europepmc   +1 more source

Phylogenetic tree of the endophagous insect species

, 2016
Leonardo Lima Bergamini, Thomas M. Lewinsohn, Leonardo Ré Jorge, Mário Almeida‐Neto   +3 more
openalex   +1 more source

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Detection and Genetic Diversity of Heritable Bacterial Symbionts in Human Lice Based on 16S-rRNA Gene. [PDF]

Environ Microbiol Rep
Marteau A, Brun S, Izri A, Akhoundi M.
europepmc   +1 more source

Anatomical Associations Between Focal Mitochondrial Metabolism and Patterns of Neurodegeneration in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) has a very specific neuroimaging signature, but the molecular underpinnings of the strikingly selective anatomic involvement have not elucidated to date. Accordingly, a large neuroimaging study was conducted with 258 participants to evaluate associations between patterns of neurodegeneration and focal ...
Marlene Tahedl, We Fong Siah, Efstratios Karavasilis, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Foteini Christidi, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Mitochondrial Genome Characterization of Six Spiny Crawler Mayflies and Comparative Analysis Within Ephemerellidae (Ephemeroptera: Pannota). [PDF]

Ecol Evol
Xue C, Ma Z, Liu D, Li R, Yi X.
europepmc   +1 more source

Biodiversity and in silico phylogenetic analysis of Tapanuli Orangutan food in the Batang Toru Forest, North Sumatra

Herna Febrianty Sianipar, Muhammad Hermawan Widyananda, Wahyu Widoretno, Luchman Hakim, Rezi Rahmi Amolia, Fatchiyah Fatchiyah   +5 more
openalex   +2 more sources