Results 161 to 170 of about 2,225,191 (247)

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +2 more sources

Global Changes in Lepidopteran Phylogenetic Diversity Across Space and Time. [PDF]

Ecol Evol
Muirberry J, Lancaster LT.
europepmc   +1 more source

Hemp Cultivation and Crop Diversification: Implications for Ecosystem Services in Kentucky

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study examines the ecosystem benefits of expanding hemp cultivation by assessing its impact on crop diversity. Using scenario‐based simulations and fixed‐effect panel regressions with county‐level data in Kentucky, we find that increased hemp acreage tends to enhance crop diversity, improving water quality and bird diversity.
Yunsun Park, Seong D. Yun, Brandy E. Phipps, Tyler Mark, Craig Schluttenhofer   +4 more
wiley   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Habitat-specific trends in taxonomic, functional, and phylogenetic diversity in European plant communities over a century. [PDF]

Nat Commun
Kambach S, Jandt U, Acosta ATR, Álvarez-Martínez JM, Axmanová I, Bazzichetto M, Bergmeier E, Bernhardt-Römermann M, Biurrun I, Bonari G, Carboni M, Carlucci MB, Carranza ML, Cerabolini BEL, Chiarucci A, Chytrý M, Damasceno G, Dengler J, De Sanctis M, Divíšek J, Dolezal J, Dullinger S, Essl F, Friesová K, Fontana V, Garbolino E, Glaser M, González-Robles A, Güler B, Hähn GJA, Hájek M, Hruska T, Illa E, Jansen F, Jansen S, Jentsch A, Jiménez-Alfaro B, Daniel Kissling W, Knollová I, Losapio G, Liu U, Lenoir J, Lens F, Lenzner B, Perea AJ, Méndez L, Messier J, Mori AS, Napoleone F, Norum R, Novakovskiy A, Onstein R, Pakeman RJ, Peñuelas J, Petřík P, Pielech R, Pinho BX, Poschlod P, Rašomavičius V, Roscher C, Rossi C, Sabatini FM, Sandel B, Costa DS, Schmidt W, Sheremetiev S, Shovon TA, Spasojevic MJ, Swenson NG, Swacha G, Tarifa R, Tichý L, Tomaselli M, Valdés A, Van Meerbeek K, Vandvik V, Vassilev K, Večeřa M, Weiher E, Wohlgemuth T, Bruelheide H.   +80 more
europepmc   +1 more source

Harnessing Large Language Models to Advance Microbiome Research: From Sequence Analysis to Clinical Applications

Advanced Intelligent Discovery, EarlyView.
Large language models are transforming microbiome research by enabling advanced sequence profiling, functional prediction, and association mining across complex datasets. They automate microbial classification and disease‐state recognition, improving cross‐study integration and clinical diagnostics.
Jieqi Xing, He Wang, Yangyang Sun, Xiaoquan Su, Shunyao Wu   +4 more
wiley   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

The interactions between climate and soil factors influence the taxonomic and phylogenetic diversity of woody plants in the subtropical karst region. [PDF]

PeerJ
Zhou R, Shi W, Yi Y, Wu Y, Tang X, Mao Y, Wang X.   +6 more
europepmc   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

A Conserved Isoleucine Gates the Diffusion of CO and O2 to the Active Site of NiFe CO‐Dehydrogenase

Angewandte Chemie, EarlyView.
A combination of protein film electrochemistry and site‐directed mutagenesis shows that isoleucine 563 (numbering of Thermococcus sp. AM4) gates the arrival of both CO and O2 to the active site of the nickel‐iron CO dehydrogenases. Mutations at this position increase the resistance to O2 at the cost of a slower reaction with CO.
Laura Opdam, Marta Meneghello, Chloé Guendon, Jade Chargelègue, Andrea Fasano, Aurore Jacq‐Bailly, Christophe Léger, Vincent Fourmond   +7 more
wiley   +2 more sources