Results 51 to 60 of about 2,225,191 (247)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Two new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages [PDF]

, 2012
There is increasing evidence that strain variation in Mycobacterium tuberculosis complex (MTBC) might influence the outcome of tuberculosis infection and disease.
Coscollà Mireia, David Stucki, Feldmann, Julia, Yeboah-Manu, D., Comas Iñaki, Gagneux, Sebastien, Hostettler Simon, Simon Hostettler, Thembela Huna (149818), Huna, Thembela, Huna Thembela, Malla Bijaya, Mireia Coscollà, Julia Feldmann (149820), Feldmann Julia, Stucki, David, Iñaki Comas (57109), Thembela Huna, Hostettler, S., Comas, Iñaki, Malla, Bijaya, Stucki David, Dorothy Yeboah-Manu, Sonia Borrell, David Stucki (149811), Huna, T., Gagneux, S., Yeboah-Manu, Dorothy, Fenner, Lukas, Borrell, Sonia, Dorothy Yeboah-Manu (120059), Comas, I., Bijaya Malla, Gagneux Sebastien, Fenner, L., Borrell Sonia, Hostettler, Simon, Lukas Fenner, Fenner Lukas, Bijaya Malla (149813), Sebastien Gagneux (149824), Mireia Coscollà (149823), Coscollà, Mireia, Sebastien Gagneux, Malla, B., Simon Hostettler (149816), Sonia Borrell (149821), Borrell, S., Julia Feldmann, Coscolla, M., Yeboah-Manu Dorothy, Lukas Fenner (149822), Iñaki Comas, Feldmann, J., Stucki, D.   +54 more
core   +3 more sources

Comparing functional and phylogenetic diversity of copepod communities in the Mediterranean Sea

, 2017
The diversity of natural communities is classically estimated through species identification (taxonomic diversity) but can also be estimated from the ecological functions performed by the species (functional diversity), or from the phylogenetic ...
Guilhaumon, F., Benedetti, F., Terbıyık Kurt, Tuba, Cornils, A., Ayata, Sakina-Dorothée, Blanco Bercial, L.   +5 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Taxonomic, Phylogenetic, and Functional Diversity of Ferns at Three Differently Disturbed Sites in Longnan County, China

, 2020
Human disturbances are greatly threatening to the biodiversity of vascular plants. Compared to seed plants, the diversity patterns of ferns have been poorly studied along disturbance gradients, including aspects of their taxonomic, phylogenetic, and ...
Xiaohua Dai, Xuexiong Wang, Chunfa Chen, Zhongyang Li   +3 more
core   +1 more source

Evolution of microgastropods (Ellobioidea, Carychiidae): integrating taxonomic, phylogenetic and evolutionary hypotheses [PDF]

, 2013
BACKGROUND: Current biodiversity patterns are considered largely the result of past climatic and tectonic changes. In an integrative approach, we combine taxonomic and phylogenetic hypotheses to analyze temporal and geographic diversification of epigean (
Annette Klussmann-Kolb, Schnitzler, Jan, Adrienne Jochum, Jan nges ar Schnitzler, Alexander M Weigand, Slapnik, Rajko, Jan Schnitzler, Zarza, Eugenia, Eugenia Zarza, Jochum, Adrienne, Weigand, Alexander, Klussmann-Kolb, Annette, Weigand, Alexander M, Rajko Slapnik   +13 more
core   +1 more source

Building a Robust, Densely-Sampled Spider Tree of Life for Ecosystem Research

Diversity, 2020
Phylogenetic relatedness is a key diversity measure for the analysis and understanding of how species and communities evolve across time and space.
Nuria Macías-Hernández, Marc Domènech, Pedro Cardoso, Brent C. Emerson, Paulo Alexandre Vieira Borges, Jesús Lozano-Fernandez, Octávio S. Paulo, Ana Vieira, Alba Enguídanos, François Rigal, Isabel R. Amorim, Miquel A. Arnedo   +11 more
doaj   +1 more source

Warming alters elevation distributions of soil bacterial and fungal communities in alpine grasslands

Global Ecology and Conservation, 2022
It is still unknown whether climate warming can change the elevation distribution of soil microbial communities in alpine grasslands. Both species and phylogenetic β-diversity of soil bacterial and fungal communities were investigated at three alpine ...
Fusong Han, Chengqun Yu, Gang Fu
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source