Results 61 to 70 of about 30,747 (258)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Phylogenetic Web Profiler [PDF]
Bioinformatics, 2003 Abstract Summary: Phylogenetic Web Profiler (PWP) is a web-based service designed to perform phylogenetic profiling of proteins against genomes. The current version offers a selection of 63 completed genomes and available plasmids as annotated in the PEDANT genome database.
Philip Wong +3 more
openaire +3 more sources
The dawn of relaxed phylogenetics.
PLoS Biology, 2023 Tracing the history of evolution across time is a primary goal of evolutionary biology. The 2006 publication of a landmark study on relaxed phylogenetics in PLOS Biology enabled biologists to shed light on evolution's tempo and shaped the future of ...
Jacob L Steenwyk, Antonis Rokas
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Survey of molecular phylogenetics
Plant, Soil and Environment, 2007 Rapidly increasing amount of biological data necessarily requires techniques that would enable to extract the information hidden in the data. Methods of molecular phylogenetics are commonly used tools as well as objects of continuous research within many
M. Talianová
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Phylogenetic Insights on Patterns of HIV-1 Spread and the Design of Epidemic Control Measures
Viruses, 2022 Phylogenetics provides a unique structural framework to track the spread of viral diseases, such as HIV-1 (human immunodeficiency virus type 1), the causative agent of AIDS (acquired immunodeficiency syndrome) [...]
Bluma G. Brenner
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Phylogenetics and the Human Microbiome [PDF]
Systematic Biology, 2014 The human microbiome is the ensemble of genes in the microbes that live inside and on the surface of humans. Because microbial sequencing information is now much easier to come by than phenotypic information, there has been an explosion of sequencing and genetic analysis of microbiome samples.
openaire +3 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Structural Phylogenetics with Confidence
Molecular Biology and Evolution, 2020 Abstract For evaluating the deepest evolutionary relationships among proteins, sequence similarity is too low for application of sequence-based homology search or phylogenetic methods. In such cases, comparison of protein structures, which are often better conserved than sequences, may provide an alternative means of uncovering deep ...
Malik AJ, Poole AM, Allison JR
openaire +5 more sources