Results 121 to 130 of about 548,823 (344)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Importance of the postcranial skeleton in eusuchian phylogeny: Reassessing the systematics of allodaposuchid crocodylians

, 2021
Alejandro Blanco
openalex   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The complete mitochondrial genome of the deep-sea paskentanid snail Alviniconcha marisindica (Caenogastropoda: abyssochrysoidea) from the Carlsberg Ridge

Mitochondrial DNA. Part B. Resources
Alviniconcha marisindica Okutani 2014 is a deep-sea gastropod inhabited in hydrothermal vents of the Indo-Pacific. It belongs to superfamily Abyssochrysoidea. In the present study, we report the complete mitochondrial genome of A.
Mei Yang, Hongliang Wang, Wei Gao, Zhinbin Gan, Xinzheng Li   +4 more
doaj   +1 more source

Phylogeny of the great cats (Felidae: Pantherinae), and the influence of fossil taxa and missing characters [PDF]

, 2008
Per Christiansen
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Is it time to switch to a formulation other than the live attenuated poliovirus vaccine to prevent poliomyelitis?

Frontiers in Public Health
The polioviruses (PVs) are mainly transmitted by direct contact with an infected person through the fecal-oral route and respiratory secretions (or more rarely via contaminated water or food) and have a primary tropism for the gut.
Christian Albert Devaux, Christian Albert Devaux, Pierre Pontarotti, Pierre Pontarotti, Anthony Levasseur, Philippe Colson, Didier Raoult   +6 more
doaj   +1 more source

Introduction of Fusarium sp. UTMC 5039 as a potent fungal strain for biosurfactant production and evaluation of its potential for crude oil bioremediation [PDF]

Biological Journal of Microorganism, 2017
Introduction: Biosurfactants are biological surface active agents which are used in many applications such as oil bioremediation of contaminated soils.
Hamid Moghimi, Parvin Hasani zadeh, Javad Hamedi, Rezvan Heidarytabar, Ehsan Azin   +4 more
doaj  

Genetic Variability and Phylogeny of High Risk HPV Type 16, 18, 31, 33 and 45 L1 Gene in Greek Women [PDF]

, 2011
Chara Kleio Ntova, Christine Kottaridi, Aikaterini Chranioti, Aris Spathis, Dimitrios Kassanos, Evangelos Paraskevaidis, Petros Karakitsos   +6 more
openalex   +1 more source