Results 61 to 70 of about 629,067 (399)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Phase transitions in Phylogeny [PDF]

, 2003
We apply the theory of markov random fields on trees to derive a phase transition in the number of samples needed in order to reconstruct phylogenies. We consider the Cavender-Farris-Neyman model of evolution on trees, where all the inner nodes have ...
Mossel, Elchanan
core   +4 more sources

Food Webs: Experts Consuming Families of Experts

, 2005
The question what determines the structure of natural food webs has been listed among the nine most important unanswered questions in ecology. It arises naturally from many problems related to ecosystem stability and resilience.
Amemiya, T., Itoh, K., Matsuda, H., Rossberg, A. G.   +3 more
core   +1 more source

Convergence and divergence in the evolution of cat skulls: temporal and spatial patterns of morphological diversity [PDF]

, 2012
Background: Studies of biological shape evolution are greatly enhanced when framed in a phylogenetic perspective. Inclusion of fossils amplifies the scope of macroevolutionary research, offers a deep-time perspective on tempo and mode of radiations ...
A Turner, Anjali Goswami, B Sidlauskas, C Clabaut, CT Stayton, D Adler, D Geraads, D Schluter, DL Swofford, E Paradis, FJ Rohlf, FJ Rohlf, FL Bookstein, FL Sicuro, FL Sicuro, GJ Slater, GJ Slater, J Burger, J Felsenstein, J Leidy, J Meachen–Samuels, JAF Diniz–Filho, JE Mosimann, JR Stone, K Seymour, L Schmitz, L Werdelin, L Werdelin, L Werdelin, L Werdelin, L Werdelin, L-P Liu, LJ Revell, M Sakamoto, M Sakamoto, Manabu Sakamoto, Marcello Ruta, ME Sunquist, MJ Salesa, MJ Salesa, P Christiansen, P Christiansen, PA Goloboff, PH Harvey, R Barnett, R Barnett, RB Sookias, S Brusatte, S Kembel, SJ Roussiakis, SL Brusatte, SP Blomberg, T Deng, T Rothwell, WC Wozencraft, WE Johnson, WL Jungers, WP Maddison, Ø Hammer   +58 more
core   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

ViCTree: an automated framework for taxonomic classification from protein sequences [PDF]

, 2018
Motivation: The increasing rate of submission of genetic sequences into public databases is providing a growing resource for classifying the organisms that these sequences represent.
Adams, Adams, Altschul, Andrew J Davison, Anil S Thanki, Bao, Cotmore, Di Tommaso, Edgar, Fu, Hibbett, Izquierdo-Carrasco, Janet Kelso, Joseph Hughes, Kapli, Katoh, Katoh, Kozlov, Lauber, Löytynoja, Löytynoja, Nishimura, Sejal Modha, Sievers, Simmonds, Simmonds, Smith, Stamatakis, Susan F Cotmore, Thompson, Vilella, Wu   +31 more
core   +1 more source

A new subfamily classification of the leguminosae based on a taxonomically comprehensive phylogeny

, 2017
The classification of the legume family proposed here addresses the long-known non-monophyly of the traditionally recognised subfamily Caesalpinioideae, by recognising six robustly supported monophyletic subfamilies.
N. Azani, M. Babineau, C. Bailey, H. Banks, A. R. Barbosa, R. B. Pinto, J. Boatwright, L. Borges, Gillian Brown, Anne Bruneau, E. S. Cândido, D. Cardoso, Kuo-Fang Chung, Ruth P. Clark, A. S. Conceição, M. Crisp, P. Cubas, A. Delgado-Salinas, K. Dexter, J. Doyle, J. Duminil, A. Egan, M. Estrella, M. J. Falcão, D. Filatov, A. P. Fortuna-Perez, R. Fortunato, E. Gagnon, P. Gasson, J. G. Rando, A. M. Tozzi, Bee F. Gunn, D. Harris, E. Haston, J. Hawkins, P. Herendeen, C. Hughes, J. Iganci, F. Javadi, S. Kanu, S. Kazempour-Osaloo, G. Kite, B. Klitgaard, F. J. Kochanovski, E. Koenen, L. Kovar, M. Lavin, M. Roux, G. Lewis, H. C. Lima, M. C. López-Roberts, B. Mackinder, V. H. Maia, V. Malécot, V. Mansano, Brigitte Marazzi, S. Mattapha, Joseph T. Miller, Chika Mitsuyuki, T. M. Moura, D. Murphy, M. Nageswara-Rao, B. Nevado, D. M. Neves, D. I. Ojeda, R. Pennington, D. Prado, G. Prenner, L. P. Queiroz, Gustavo Ramos, F. Filardi, P. G. Ribeiro, M. D. L. Rico-Arce, M. Sanderson, Juliana Santos-Silva, Wallace M. B. São-Mateus, Marcos J. Silva, M. Simon, Carole Sinou, Cristiane Snak, É. R. Souza, J. Sprent, K. Steele, Julia E. Steier, R. Steeves, C. Stirton, S. Tagane, B. Torke, Hironori Toyama, Daiane Trabuco da Cruz, M. Vatanparast, J. Wieringa, M. Wink, M. Wojciechowski, T. Yahara, T. Yi, E. Zimmerman   +96 more
semanticscholar   +1 more source

Revisiting metazoan phylogeny with genomic sampling of all phyla

Proceedings of the Royal Society B, 2019
Proper biological interpretation of a phylogeny can sometimes hinge on the placement of key taxa—or fail when such key taxa are not sampled. In this light, we here present the first attempt to investigate (though not conclusively resolve) animal ...
C. Laumer, R. Fernández, S. Lemer, David J. Combosch, K. Kocot, A. Riesgo, S. Andrade, W. Sterrer, M. Sørensen, Gonzalo Giribet   +9 more
semanticscholar   +1 more source