Results 1 to 10 of about 4,321 (234)

Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes [PDF]

Pharmaceutical Biology
Context The effect of the active ingredients in traditional Chinese medicines on the activity of cytochrome P450 enzymes (CYP450s) is a critical factor that should be considered in TCM prescriptions.
Lu Liu, Sen Sun, Xiaohua Li
doaj   +7 more sources

Discovery of Cortinarius O-methyltransferases for the heterologous production of dermolutein and physcion. [PDF]

Biotechnol Biofuels Bioprod
Background: Anthraquinones in the emodin family are produced by bacteria, fungi, and plants. They display various biological activities exploited, e.g., for crop protection, and may also be utilized as sustainable, bio-based colorants for the textile ...
Jetha P, Mojzita D, Maiorova N, de Ruijter JC, Maaheimo H, Hilditch S, Peddinti G, Castillo S, Toivari M, Penttilä M, Molnár I.   +10 more
europepmc   +11 more sources

Physcion Induces Potential Anticancer Effects in Cervical Cancer Cells [PDF]

Cells, 2021
Background: The extent of morphological and ultrastructural changes in HeLa cells was assessed by optical, fluorescence and electron microscopy after exposure to various concentrations of physcion, taking into account the biological properties of the ...
Wojciech Trybus, Teodora Król, Ewa Trybus, Anna Stachurska   +3 more
doaj   +6 more sources

Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models [PDF]

Biological Research
Background Pain serves as a vital protective mechanism triggered by tissue damage. While NSAIDs and opioids offer relief, their prolonged usage is hindered by adverse effects.
Hanbin Chen, Guanghong Li, Lin Deng, Shuli Li, Songqiang Huang, Simon Ming-Yuen Lee, Xiaowei Nie, Jin-Song Bian   +7 more
doaj   +5 more sources

Study on the effect of processing methods on the total polyphenol, 2,3,5,4’-tetrahydroxystilben-2-O-β-D-glucoside, and physcion contents in Fallopia multiflora Thunb. Haraldson root [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2023
This study investigated the changes in the ingredients in Fallopia multiflora Thunb. Haraldson (FMT) root after processing it with different methods such as soaking, stewing, and steaming or combined methods.
Nguyen Thi Hong Thanh, Nguyen Thi Hong Tham, Tran Dinh Thang, Nguyen Thuy Chinh, Nguyen Dinh Luyen, Bui Thi Thuy Luyen   +5 more
doaj   +6 more sources

Multi-layered engineering of Aspergillus terreus enhances biosynthesis of the plant-derived fungicide physcion [PDF]

Microbial Cell Factories
Background Emodin and its derivatives are important bioactive anthraquinones from rhubarb, with diverse pharmacological activities. Physcion, an O-methylated derivative of emodin, is a promising plant-derived fungicide and pharmaceutical lead.
Zilin Ren, Yingying Xue, Ning Xu, Dandan Feng, Ce Geng, Yongsong Wu, Dan Liu, Linshui Zhao, Xiaoxi Zhang, Honglei Ma, Xuenian Huang, Feifei Qi, Xuefeng Lu   +12 more
doaj   +8 more sources

Physcion Mitigates LPS-Induced Neuroinflammation, Oxidative Stress, and Memory Impairments via TLR-4/NF-кB Signaling in Adult Mice [PDF]

Pharmaceuticals
Alzheimer’s disease (AD) is the most predominant cause of dementia, considered a progressive decline in cognitive function that ultimately leads to death.
Sareer Ahmad, Kyonghwan Choe, Haroon Badshah, Riaz Ahmad, Waqar Ali, Inayat Ur Rehman, Tae Ju Park, Jun Sung Park, Myeong Ok Kim   +8 more
doaj   +5 more sources

Production of the antifungal biopesticide physcion through the combination of microbial fermentation and chemical post-treatment [PDF]

Bioresources and Bioprocessing, 2023
Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide.
Zheng Zhuang, Xueqing Zhong, Qinghua Li, Tian Liu, Qing Yang, Guo-Qiang Lin, Qing-Li He, Qunfei Zhao, Wen Liu   +8 more
doaj   +3 more sources

Physcion ameliorates pancreatic β-cell dysfunction and diabetes-related oxidative stress markers in type 2 diabetes rat model

Phytomedicine Plus, 2021
Background: Physcion is an active component of Rheum officinale Baill, a popular traditional Chinese medicine used locally to treat diabetes. Previous studies revealed that physcion possessed antidiabetic activity of physcion using various in vitro ...
Alonyenu Edwin Inalegwu, Idowu Asegame Aimola, Aminu Mohammed   +2 more
doaj   +3 more sources

Optimization of fermentation conditions for physcion production of Aspergillus chevalieri BYST01 by response surface methodology [PDF]

PeerJ
This study aimed to optimize the culture conditions of the termite-derived fungus Aspergillus chevalieri BYST01 for the production of physcion, a characteristic component of the traditional herb rhubarb, which has been commercially approved as a ...
Shuxiang Zhang, Zhou Jiang, Suwen An, Xiaolan Jiang, Yinglao Zhang   +4 more
doaj   +4 more sources