Results 11 to 20 of about 1,757 (151)

Physcion inhibition of CYP2C9, 2D6 and 3A4 in human liver microsomes [PDF]

Pharmaceutical Biology
Context The effect of the active ingredients in traditional Chinese medicines on the activity of cytochrome P450 enzymes (CYP450s) is a critical factor that should be considered in TCM prescriptions.
Lu Liu, Sen Sun, Xiaohua Li
doaj   +4 more sources

Association of Physcion and Chitosan Can Efficiently Control Powdery Mildew in Rosa roxburghii

Antibiotics, 2022
Powdery mildew is an extremely serious disease of all Rosa roxburghii production regions in China and frequently causes 30~40% of economic losses. Natural products are considered excellent alternatives to chemical fungicides.
Cheng Zhang, Jiaohong Li, Yue Su, Xiaomao Wu   +3 more
doaj   +3 more sources

Physcion Mitigates LPS-Induced Neuroinflammation, Oxidative Stress, and Memory Impairments via TLR-4/NF-кB Signaling in Adult Mice [PDF]

Pharmaceuticals
Alzheimer’s disease (AD) is the most predominant cause of dementia, considered a progressive decline in cognitive function that ultimately leads to death.
Sareer Ahmad, Kyonghwan Choe, Haroon Badshah, Riaz Ahmad, Waqar Ali, Inayat Ur Rehman, Tae Ju Park, Jun Sung Park, Myeong Ok Kim   +8 more
doaj   +2 more sources

Inhibition of 6-phosphogluconate dehydrogenase suppresses esophageal squamous cell carcinoma growth and enhances the anti-tumor effects of metformin via the AMPK/mTOR pathway [PDF]

Molecular Cancer
Metabolic reprogramming plays a pivotal role in the development and progression of tumors. Tumor cells rely on glycolysis as their primary energy production pathway and effectively utilize biomolecules generated by the pentose phosphate pathway (PPP) for
Bei Wang, Zixuan Wang, Zini Zhou, Gui Liu, Zhenyuan Jiang, Mingyue Zheng, Wei Geng   +6 more
doaj   +2 more sources

<i>Rumex</i> Species: Phytochemistry, Pharmacology and Nutritional Potential for Food and Health Applications. [PDF]

Food Sci Nutr
Rumex dentatus, R. vesicarius, and Emex spinosa are traditionally used for managing gastrointestinal, respiratory, hepatic, and inflammatory disorders. In addition to their ethnomedicinal value, some species are consumed as wild edibles. Pharmacological studies support their antimicrobial, antioxidant, hepatoprotective, cytotoxic, and antidiabetic ...
Mohamed Gohar M, Ezzat SM, Yeskaliyeva B, Elhawary SS, Kirollos FN, Khouchlaa A, Bouyahya A, Calina D, Sharifi-Rad J, Setzer WN, Martorell M.   +10 more
europepmc   +2 more sources

Estrogenic activities of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside and physcion in MCF-7 cells

Medicine in Drug Discovery, 2021
Polygonum multiflorum (PM) is a perennial herbal medicine that inhibits osteopenia of osteoporosis caused by estrogen deficiency and shows estrogen-like activity.
Su-Jin Kim, Yun-Ho Hwang, Sung-Tae Yee
doaj   +1 more source

Physcion Protects Against Ethanol-Induced Liver Injury by Reprogramming of Circadian Clock

Frontiers in Pharmacology, 2020
The circadian clock plays a key role in our daily physiology and metabolism. Alcohol consumption disrupts the circadian rhythm of metabolic genes in the liver; however, the potential contribution of circadian clock modulation to alcoholic liver disease ...
Youli Yao, Along Zuo, Qiyu Deng, Shikang Liu, Tianying Zhan, Maolin Wang, Haidong Xu, Junxian Ma, Yingying Zhao   +8 more
doaj   +1 more source

Discovery of Cortinarius O-methyltransferases for the heterologous production of dermolutein and physcion. [PDF]

Biotechnol Biofuels Bioprod
Anthraquinones in the emodin family are produced by bacteria, fungi, and plants. They display various biological activities exploited, e.g., for crop protection, and may also be utilized as sustainable, bio-based colorants for the textile, paints, electronics, and cosmetic industries. Anthraquinone pigments from Cortinarius mushrooms have been used for
Jetha P, Mojzita D, Maiorova N, de Ruijter JC, Maaheimo H, Hilditch S, Peddinti G, Castillo S, Toivari M, Penttilä M, Molnár I.   +10 more
europepmc   +4 more sources

Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes

Biological and Pharmaceutical Bulletin, 2021
The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, the suicidal cell death of red blood cells (RBCs), may account for CIA as it is triggered by clinically approved chemotherapeutics including cisplatin and paclitaxel. Physcion (PSN), an anthraquinone extracted from
Akiel, Maaged, Alsughayyir, Jawaher, Basudan, Ahmed M., Alamri, Hassan S., Dera, Ayed, Barhoumi, Tlili, Al Subayyil, Abdullah M., Basmaeil, Yasser S., Aldakheel, Fahad M., Alakeel, Raid, Ghneim, Hazem K., Al-Sheikh, Yazeed A., Alraey, Yasser, Asiri, Saeed, Alfhili, Mohammad A.   +14 more
openaire   +3 more sources

Physcion reduces lipid accumulation and prevents the obesity in mice [PDF]

Nutrition & Metabolism, 2019
Obesity increases the risk of metabolic dysfunction such as dyslipidemia, hypertension, and fatty liver. Physcion (PY) is an anthraquinone that reportedly has anti-inflammatory and anti-bacterial properties. However, few studies have addressed the effect of PY on high-fat diet-induced obesity in mice.
Seon-Jeong Lee, Su-Jung Cho, Eun-Young Kwon, Myung-Sook Choi   +3 more
openaire   +3 more sources