2,3,5,4′-Tetrahydroxystilbene (TG1), a Novel Compound Derived from 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG), Inhibits Colorectal Cancer Progression by Inducing Ferroptosis, Apoptosis, and Autophagy [PDF]
Biomedicines, 2023 Background: Colorectal cancer (CRC) is one of the deadliest cancers worldwide and long-term survival is not guaranteed in metastatic disease despite current multidisciplinary therapies.
Hsin-An Chen, Kuei-Yen Tsai, Po-Li Wei
exaly +7 more sources
THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation [PDF]
Scientific ReportsMicroglial activation, driven by a metabolic shift towards aerobic glycolysis, is implicated in neuroinflammation and neurological disorders like depression.
Yingyu Sun
exaly +5 more sources
2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside Attenuates Reactive Oxygen Species-Dependent Inflammation and Apoptosis in Porphyromonas gingivalis-Infected Brain Endothelial Cells [PDF]
Antioxidants, 2022 We recently reported that the periodontopathic bacteria Porphyromonas gingivalis (P. gingivalis) initiates an inflammatory cascade that disrupts the balance of reactive oxygen species (ROS), resulting in apoptotic cell death in brain endothelial cells ...
Vichuda Charoensaensuk +5 more
doaj +3 more sources
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside improves female ovarian aging [PDF]
Frontiers in Cell and Developmental Biology, 2022 Reduced fertility associated with normal aging may reflect the over-maturity of oocytes. It is increasingly important to reduce aging-induced infertility since recent trends show people marrying at later ages.
Yu-Chen S H Yang, Yi-Fong Chen
exaly +4 more sources
2,3,5,4′-tetrahydroxystilbene-2-O-b-D-glucoside triggers the pluripotent-like possibility of dental pulp stem cells by activating the JAK2/STAT3 axis: Preliminary observations [PDF]
Journal of Dental Sciences, 2021 Background/Purpose: Although 2,3,5,4′-Tetrahydroxystilbene-2-O-beta-glucoside (THSG) reportedly has anti-inflammatory properties, its role in inducing the dedifferentiation of human dental pulp stem cells (DPSC) into pluripotent-like stem cells remains ...
Yen-Wen Huang +10 more
doaj +3 more sources
2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside ameliorates bleomycin-induced pulmonary fibrosis via regulating pro-fibrotic signaling pathways [PDF]
Frontiers in Pharmacology, 2022 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside (THSG) is the main active ingredient extracted from Polygonum multiflorum Thunb. (PMT), which has been reported to possess extensive pharmacological properties.
Tsung-Teng Huang +12 more
doaj +2 more sources
2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside-stimulated dental pulp stem cells-derived conditioned medium enhances cell activity and anti-inflammation [PDF]
Journal of Dental Sciences, 2021 Background/purpose: Dental pulp stem cells (DPSCs) contribute to the regeneration of various tissues and have superior proliferation, immune privilege, and anti-inflammation properties to other mesenchymal stem cells.
Yu-tang Chin +9 more
doaj +2 more sources
Comparison of 2,3,5,4′-tetrahydroxystilbene-2-O-b-D-glucoside-induced proliferation and differentiation of dental pulp stem cells in 2D and 3D culture systems—gene analysis [PDF]
Journal of Dental Sciences, 2022 Background/purpose: Culture environments play a critical role in stem cell expansion. This study aimed to evaluate the effects of 2,3,5,4′-tetrahydroxystilbene-2-O-b-D-glucoside (THSG) on the proliferation and differentiation of human dental pulp stem ...
Yen Wu +10 more
doaj +2 more sources
Molecular identification and functional characterization of two glycosyltransferases genes from Fallopia multiflora [PDF]
Frontiers in Plant Science, 2022 The traditional Chinese medicine plant Fallopia multiflora (Thunb.) Harald. contains various pharmacodynamically active glycosides, such as stilbene glycosides, anthraquinone (AQ) glycosides, and flavonoid glycosides.
Qizhong Cai +13 more
doaj +2 more sources
Transformation of Stilbene Glucosides From Reynoutria multiflora During Processing [PDF]
Frontiers in Pharmacology, 2022 The root of Reynoutria multiflora Thunb. Moldenke (RM, syn.: Polygonum multiflorum Thunb.) has been widely used in TCM clinical practice for centuries. The raw R.
Junqi Bai +14 more
doaj +2 more sources