Beneficial Effects of THSG on Acetic Acid-Induced Experimental Colitis: Involvement of Upregulation of PPAR-γ and Inhibition of the Nf-Κb Inflammatory Pathway [PDF]
Molecules, 2011 The polyphenolic compound 2,3,5,4′-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG) has been shown to possess anti-inflammatory effects. Here, we examined the effects of THSG on experimental mice with colitis induced by acetic acid and whether the ...
Mu-Jun Chang +2 more
exaly +6 more sources
2,3,4′,5-Tetrahydroxystilbene-2-O-β-D-Glucoside (THSG) Activates the Nrf2 Antioxidant Pathway and Attenuates Oxidative Stress-Induced Cell Death in Mouse Cochlear UB/OC-2 Cells [PDF]
Biomolecules, 2020 Oxidative stress plays a critical role in the pathogenesis of hearing loss, and 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) exerts antioxidant effects by inhibiting reactive oxygen species (ROS) generation.
Tien-Yuan Wu +5 more
doaj +4 more sources
NCAPD3-mediated ferroptosis of 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells [PDF]
Frontiers in PharmacologyObjectiveNon-SMC condensin II complex subunit D3 (NCAPD3) has recently been demonstrated as a crucial oncogenic factor, nevertheless, the biological role of NCAPD3 in the pathogenesis of breast cancer has not been elucidated.
Jianfen Shen +12 more
doaj +4 more sources
Otoprotective Effect of 2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-Glucoside on Gentamicin-Induced Apoptosis in Mouse Cochlear UB/OC-2 Cells [PDF]
Molecules, 2020 Excessive levels of reactive oxygen species (ROS) lead to mitochondrial damage and apoptotic cell death in gentamicin-induced ototoxicity. 2,3,4’,5-Tetrahydroxystilbene-2-O-β-d-glucoside (THSG), a bioactive constituent, isolated from Polygonum ...
Yu-Hsuan Wen +6 more
doaj +3 more sources
Attempt to Synthesize 2,3,5,4′-Tetrahydroxystilbene Derived from 2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside (THSG) [PDF]
Chemical & pharmaceutical bulletin, 2014 An attempt to synthesize aglycone 1 derived from 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside (THSG) via the Wittig reaction and Mizoroki?Heck reaction is described. In the Wittig protocol, 2,3,5,4'-tetramethoxystilbene 2 was obtained.
上田, 純也 +4 more
core +5 more sources
2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice. [PDF]
PLoS ONE, 2012 Oxidative stress has recently been considered as a pivotal player in the pathogenesis of diabetic gastrointestinal dysfunction. We therefore investigated the role of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG) that has a strong anti ...
Mu-Jun Chang +5 more
doaj +2 more sources
Brazilian Journal of Pharmaceutical Sciences, 2023 This study investigated the changes in the ingredients in Fallopia multiflora Thunb. Haraldson (FMT) root after processing it with different methods such as soaking, stewing, and steaming or combined methods.
Nguyen Thi Hong Thanh +5 more
doaj +3 more sources
Molecules, 2018 Polygonum multiflorum Thunb. is a traditional herbal medicine that is rich in polyphenols. The major compound, 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside (THSG) has many pharmacological activities, such as antioxidative and free radical-scavenging ...
Po-Wei Tsai +4 more
doaj +2 more sources
Integrated chemometric evaluation of morphological traits, chemical composition, and hepatotoxicity of Polygonum multiflorum [PDF]
Frontiers in PharmacologyEthnopharmacological relevanceThe toxicity of Polygonum multiflorum (PM) is widely recognized. However, its toxic constituents and the mechanisms underlying their interactions remain insufficiently characterized.AimThis study aims to establish a new ...
Yanyi Li +4 more
doaj +2 more sources
Triptolide alleviates hyperosmotic stress-induced human corneal epithelial cell damage by inhibiting NLRP3 inflammasome-mediated pyroptosis via the TLR4/NF-κB pathway [PDF]
Frontiers in MedicinePurposeTo verify that Triptolide alleviates hyperosmotic stress-induced damage to human corneal epithelial cells (HCECs) by suppressing pyroptosis via the Toll-like receptor 4/nuclear factor-κB/NOD-like receptor family, pyrin domain-containing 3 (TLR4/NF-
Ran Xia +4 more
doaj +2 more sources