Phytomedicine Plus, 2021 Background: Physcion is an active component of Rheum officinale Baill, a popular traditional Chinese medicine used locally to treat diabetes. Previous studies revealed that physcion possessed antidiabetic activity of physcion using various in vitro ...
Aminu Mohammed
exaly +3 more sources
Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models [PDF]
Biological ResearchBackground Pain serves as a vital protective mechanism triggered by tissue damage. While NSAIDs and opioids offer relief, their prolonged usage is hindered by adverse effects.
Hanbin Chen +7 more
doaj +2 more sources
Gut microbiota and HMGB1/NLRP3/GSDMD inflammasome-dependent pyroptosis: mechanisms by physcion ameliorates alcoholic liver fibrosis [PDF]
Frontiers in PharmacologyAlcoholic liver fibrosis (ALF) developed from long-term excessive alcohol consumption, which causes inflammatory reactions, lipid accumulation and cirrhosis.
Ting Bai +7 more
doaj +2 more sources
Bioresources and Bioprocessing, 2023 Physcion is an anthraquinone compound observed dominantly in medicinal herbs. This anthraquinone possesses a variety of pharmaceutically important activities and has been developed to be a widely used antifungal biopesticide.
Qing-Li He, Tian Liu, Guo-Qiang Lin
exaly +2 more sources
Physcion Induces Potential Anticancer Effects in Cervical Cancer Cells
Cells, 2021 Background: The extent of morphological and ultrastructural changes in HeLa cells was assessed by optical, fluorescence and electron microscopy after exposure to various concentrations of physcion, taking into account the biological properties of the ...
Teodora Król +2 more
exaly +3 more sources
Optimization of fermentation conditions for physcion production of Aspergillus chevalieri BYST01 by response surface methodology [PDF]
PeerJThis study aimed to optimize the culture conditions of the termite-derived fungus Aspergillus chevalieri BYST01 for the production of physcion, a characteristic component of the traditional herb rhubarb, which has been commercially approved as a ...
Shuxiang Zhang +4 more
doaj +3 more sources
Physcion effectively mitigates ovariectomy-induced osteoporosis in mice
Medicine in Drug Discovery, 2020 Aims: In this study, an ovariectomized mouse model was used to investigate the therapeutic effect of physcion on bone loss caused by estrogen deficiency.
Sung-Ho Kim +2 more
exaly +3 more sources
Multi-layered engineering of Aspergillus terreus enhances biosynthesis of the plant-derived fungicide physcion [PDF]
Microbial Cell FactoriesBackground Emodin and its derivatives are important bioactive anthraquinones from rhubarb, with diverse pharmacological activities. Physcion, an O-methylated derivative of emodin, is a promising plant-derived fungicide and pharmaceutical lead.
Zilin Ren +12 more
doaj +2 more sources
Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed Polygonum multiflorum Thunb. using a comprehensive two-dimensional biochromatography system [PDF]
Frontiers in PharmacologyIntroductionPolygonum multiflorum Thunb. (PM) is a representative traditional Chinese medicine (TCM) that exerts different effects in raw and processed forms.
Zhihui Li +10 more
doaj +2 more sources
Exploring the efficacy of new potential bio-insecticides produced by Penicillium oxalicum against Culex pipiens larvae [PDF]
BMC MicrobiologyBackground Synthetic insecticides are major contributors to environmental pollution and the emergence of resistance. Fungal-derived metabolites are known to be environmentally friendly, selective alternatives. Thus, in the context of a green environment,
Hayam A. E. Sayed +4 more
doaj +2 more sources