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Rhein from a traditional herbal formula attenuates hepatic fibrosis via ALDH1A3-mediated retinoic acid metabolism [PDF]
Chinese MedicineBackground Hepatic fibrosis is a prevalent outcome of chronic liver diseases. Although activation of hepatic stellate cell (HSC) is a primary driver of fibrogenesis, therapeutic strategies targeting retinoic acid (RA) metabolism in HSCs remain ...
Kai Yu +10 more
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Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk [PDF]
Frontiers in PharmacologyIntroductionRhein, an anthraquinone derived from rhubarb, exhibits renoprotective effects in aging and kidney injury; however, the mechanistic interplay with TNF-α-mediated cell death pathways remains undefined.MethodsUsing D-galactose (D-gal)-treated ...
Yue Tu +11 more
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PharmaceuticalsRhein is a natural active ingredient in traditional Chinese medicine that has attracted much attention due to its wide range of pharmacological activities.
Yin Fengting, Guangli Yan
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The Phytochemical Rhein Mediates M6A-Independent Suppression of Adipocyte Differentiation
Frontiers in Nutrition, 2021 Adipogenesis is mediated by the complex gene expression networks involving the posttranscriptional modifications. The natural compound rhein has been linked to the regulation of adipogenesis, but the underlying regulatory mechanisms remain elusive ...
Linyuan Huang +9 more
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Rhein attenuates angiotensin II-induced cardiac remodeling by modulating AMPK–FGF23 signaling
Journal of Translational Medicine, 2022 Background Increasing evidence indicates that myocardial oxidative injury plays a crucial role in the pathophysiology of cardiac hypertrophy (CH) and heart failure (HF).
Wei Lu +5 more
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Natural Product Communications, 2022 It has been reported that rhein, a Chinese herbal compound, has a potent anti-inflammatory effect on various diseases. However, it remains elusive whether rhein has a protective effect on chronic kidney disease (CKD) and what its underlying mechanism may
Rongbing Xiong +4 more
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Preparation of Bioactive De-Chlorophyll Rhein-Rich Senna alata Extract
Antibiotics, 2023 Senna alata leaves display various biological activities as a result of their rhein and phenolic composition. The objective of this study was to develop bioactive de-chlorophyll rhein-rich S. alata extracts.
Wah Wah Aung +8 more
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Rhein for treating diabetes mellitus: A pharmacological and mechanistic overview
Frontiers in Pharmacology, 2023 With the extension of life expectancy and changes in lifestyle, the prevalence of diabetes mellitus is increasing worldwide. Rheum palmatum L. a natural botanical medicine, has been used for thousands of years to prevent and treat diabetes mellitus in ...
Tingting Deng +9 more
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The Effects of the Combination of Rhein and Platelet-Rich Plasma on Human Articular Chondrocytes
Life, 2023 Background: The presence of side effects and low bioavailability of rhein has limited its use in the treatment of osteoarthritis. We aimed to evaluate the in vitro response of human articular chondrocytes to the presence of the combination of platelet ...
Mario Simental-Mendía +6 more
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Journal of Orthopaedic Surgery and Research, 2023 Purpose To construct an injectable, sustained-release fibrin gel containing rhein to solve the problem of low bioavailability of rhein, and observe its efficacy in the treatment of intervertebral disc degeneration. Methods The fibrin gel containing rhein
Jianhang Bao +4 more
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