Results 1 to 10 of about 14,550 (256)

An LC-MS Method to Quantify Rhein and Its Metabolites in Plasma: Application to a Pharmacokinetic Study in Rats [PDF]

Metabolites
Background: Diacerein, a prodrug of Rhein, is commonly prescribed for the management of joint disorders, specifically osteoarthritis. This study aimed to develop and validate an LC-MS/MS method to quantify Rhein and its major metabolites, Rhein-G1 and ...
Nyma Siddiqui, Yuan Chen, Ting Du, Yang Wang, Charmeyce Buck, Song Gao   +5 more
doaj   +2 more sources

Rhein protects against renal aging and fibrotic injury by multiple targets through inhibition of TNF-α-mediated autophagy and necroptosis crosstalk [PDF]

Frontiers in Pharmacology
IntroductionRhein, an anthraquinone derived from rhubarb, exhibits renoprotective effects in aging and kidney injury; however, the mechanistic interplay with TNF-α-mediated cell death pathways remains undefined.MethodsUsing D-galactose (D-gal)-treated ...
Yue Tu, Yue Tu, Yue Tu, Wenjie Liu, Tianqing Sang, Liuyunxin Pan, Wei Wu, Qijun Fang, Yinglu Liu, Buhui Liu, Yigang Wan, Yigang Wan   +11 more
doaj   +2 more sources

Rhein: An Updated Review Concerning Its Biological Activity, Pharmacokinetics, Structure Optimization, and Future Pharmaceutical Applications

Pharmaceuticals
Rhein is a natural active ingredient in traditional Chinese medicine that has attracted much attention due to its wide range of pharmacological activities.
Wang XiJun, Kong Ling
exaly   +3 more sources

The Phytochemical Rhein Mediates M6A-Independent Suppression of Adipocyte Differentiation

Frontiers in Nutrition, 2021
Adipogenesis is mediated by the complex gene expression networks involving the posttranscriptional modifications. The natural compound rhein has been linked to the regulation of adipogenesis, but the underlying regulatory mechanisms remain elusive ...
Linyuan Huang, Jun Zhang, Xinyun Zhu, Xue Mi, Qiujie Li, Jing Gao, Jianheng Zhou, Jun Zhou, Jun Zhou, Xiao-Min Liu   +9 more
doaj   +1 more source

Rhein attenuates angiotensin II-induced cardiac remodeling by modulating AMPK–FGF23 signaling

Journal of Translational Medicine, 2022
Background Increasing evidence indicates that myocardial oxidative injury plays a crucial role in the pathophysiology of cardiac hypertrophy (CH) and heart failure (HF).
Wei Lu, Hongqiao Zhu, Jiawen Wu, Sheng Liao, Guobing Cheng, Xiaoyang Li   +5 more
doaj   +1 more source

Rhein Inhibits Proliferation, Extracellular Matrix Deposition, and Inflammation in Mesangial Cells via ROS/Akt Signaling Pathway

Natural Product Communications, 2022
It has been reported that rhein, a Chinese herbal compound, has a potent anti-inflammatory effect on various diseases. However, it remains elusive whether rhein has a protective effect on chronic kidney disease (CKD) and what its underlying mechanism may
Rongbing Xiong, Xiaodi Hu, Shuangyan Hu, Minqi Yao, Xiaojun Fu   +4 more
doaj   +1 more source

Preparation of Bioactive De-Chlorophyll Rhein-Rich Senna alata Extract

Antibiotics, 2023
Senna alata leaves display various biological activities as a result of their rhein and phenolic composition. The objective of this study was to develop bioactive de-chlorophyll rhein-rich S. alata extracts.
Wah Wah Aung, Kanokpon Panich, Suchawalee Watthanophas, Sutada Naridsirikul, Juthaporn Ponphaiboon, Wantanwa Krongrawa, Pattranit Kulpicheswanich, Sontaya Limmatvapirat, Chutima Limmatvapirat   +8 more
doaj   +1 more source

Rhein for treating diabetes mellitus: A pharmacological and mechanistic overview

Frontiers in Pharmacology, 2023
With the extension of life expectancy and changes in lifestyle, the prevalence of diabetes mellitus is increasing worldwide. Rheum palmatum L. a natural botanical medicine, has been used for thousands of years to prevent and treat diabetes mellitus in ...
Tingting Deng, Jinxin Du, Ying Yin, Baorui Cao, Zhiying Wang, Zhongwen Zhang, Meina Yang, Meina Yang, Jinxiang Han, Jinxiang Han   +9 more
doaj   +1 more source

The Effects of the Combination of Rhein and Platelet-Rich Plasma on Human Articular Chondrocytes

Life, 2023
Background: The presence of side effects and low bioavailability of rhein has limited its use in the treatment of osteoarthritis. We aimed to evaluate the in vitro response of human articular chondrocytes to the presence of the combination of platelet ...
Mario Simental-Mendía, Sonia Amelia Lozano-Sepúlveda, Marsela Garza-Tapia, Jorge Lara-Arias, Carlos Alberto Acosta-Olivo, Félix Vilchez-Cavazos, Víctor Manuel Peña-Martínez   +6 more
doaj   +1 more source

Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy

Journal of Orthopaedic Surgery and Research, 2023
Purpose To construct an injectable, sustained-release fibrin gel containing rhein to solve the problem of low bioavailability of rhein, and observe its efficacy in the treatment of intervertebral disc degeneration. Methods The fibrin gel containing rhein
Jianhang Bao, Wenshuo Gao, Wei Zhang, Dong Wang, Hao Pan   +4 more
doaj   +1 more source