Results 41 to 50 of about 76,583 (247)

How “Green” is Your Functional Material? Assessing Environmental Impacts of Multi‐Step Synthetic Protocols in Material Sciences at Various Technology Levels

Advanced Materials, EarlyView.
Environmental Synthesis Radar (ESR) evaluates the environmental impact of (early‐stage) multi‐step chemical syntheses, providing a holistic view by using 18 midpoint impact categories. Unlike conventional life‐cycle assessment (LCA) approaches, ESR reveals three complementary metrics: overall impact Vtotal, environmental hotspots VEF, and critical ...
Laura Plein, Alexander Schommer, Florian Dietrich, Moritz Gutsch, Heike Klesper, Kevin Schuller, Lars Jahnke, Jens Leker, Klaus Meerholz   +8 more
wiley   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

Internationale Schriften der Hochschule Bonn-Rhein-Sieg

, 2010
In der Reihe „Internationale Schriften der Hochschule Bonn-Rhein-Sieg“ werden in erster Linie anwendungsorientierte Studien unterschiedlicher Disziplinen im Kontext internationaler Wissenschaft, Politik und Wirtschaft veröffentlicht.
Terlau, Wiltrud (Ed.), Ihne, Hartmut (Ed.)   +1 more
core   +1 more source

Rhein promotes the proliferation of keratinocytes by targeting oestrogen receptors for skin ulcer treatment

BMC Complementary Medicine and Therapies, 2022
Background The Sheng-ji Hua-yu (SJHY) formula is a quite effective Traditional Chinese Medicines (TCM) in the treatment of delayed diabetic wounds. Previous research has shown that the SJHY formula has significant anti-inflammatory and wound-healing ...
Ning Xu, Yuanran Chen, Dongjie Guo, Yu Deng, Wanjun Guo, Xin Liu, Yi Wang, Hanzhi Lu, Aijun Liu, Jianyong Zhu, Fulun Li   +10 more
doaj   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Fachbereich Wirtschaftswissenschaften, Department of Management Sciences [PDF]

, 2015
Praxisorientierte, wissenschaftliche Lehre und Forschung in enger Zusammenarbeit mit Unternehmen, Organisationen und gesellschaftlichen Gruppierungen ist das zentrale Leitbild des Fachbereichs Wirtschaftswissenschaften an der Hochschule Bonn-Rhein-Sieg ...
Hochschule Bonn-Rhein-Sieg. Fachbereich Wirtschaftswissenschaften
core   +1 more source

Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell

Frontiers in Public Health, 2022
The global incidence of genital Chlamydia trachomatis infection increased rapidly as the primary available treatment of C. trachomatis infection being the use of antibiotics.
Xueying Yu, Xueying Yu, Qingqing Xu, Wentao Chen, Wentao Chen, Zhida Mai, Lijun Mo, Xin Su, Jiangli Ou, Yinyuan Lan, Heping Zheng, Heping Zheng, Yaohua Xue, Yaohua Xue   +13 more
doaj   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Determination of Bioactive Components in Chinese Herbal Formulae and Pharmacokinetics of Rhein in Rats by UPLC-MS/MS

Molecules, 2014
Rhein (4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid, cassic acid) is a pharmacological active component found in Rheum palmatum L. the major herb of San-Huang-Xie-Xin-Tang (SHXXT), a medicinal herbal product used as a remedy for constipation ...
Mei-Ling Hou, Li-Wen Chang, Chi-Hung Lin, Lie-Chwen Lin, Tung-Hu Tsai   +4 more
doaj   +1 more source

Foresee - recognising signs, devising solutions, shaping the future [PDF]

, 2023
Foresee means developing visions for the future and helping to shape them responsibly in close exchange between applied science, society and business. This is an important concern for the Hochschule Bonn-Rhein-Sieg.
Hochschule Bonn-Rhein-Sieg
core