Results 41 to 50 of about 14,550 (256)

Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets

Molecules, 2022
Currently, both acute kidney injury (AKI) and chronic kidney disease (CKD) are considered to be the leading public health problems with gradually increasing incidence rates around the world.
Yanna Zhu, Shilei Yang, Linlin Lv, Xiaohan Zhai, Guoyu Wu, Xiaolin Qi, Deshi Dong, Xufeng Tao   +7 more
doaj   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein

Chinese Medicine, 2023
Background Rhein can significantly delay the progression of chronic nephropathy. However, its mechanism of action has not been adequately elaborated, which hinders its extensive clinical application.
Li Wang, Xixi Yu, Hongju Li, Dahong He, Su Zeng, Zheng Xiang   +5 more
doaj   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source

Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue

International Journal of Biological Sciences, 2012
Liver X receptors (LXRs) play important roles in regulating cholesterol homeostasis, and lipid and energy metabolism. Therefore, LXR ligands could be used for the management of metabolic disorders.
Xiaoyan Sheng, Xuehua Zhu, Yuebo Zhang, Guoliang Cui, Linling Peng, Xiong Lu, Ying Qin Zang
doaj  

Synthesis and Anti-tumor Activity Evaluation of Rhein-Aloe Emodin Hybrid Molecule

Natural Product Communications, 2012
To improve the anti-tumor effects of rhein and aloe-emodin, a rhein-aloe-emodin hybrid molecule (RH-AE) was synthesized from rhein and aloe-emodin in the presence of dicyclohexylcarbodiimide (DCC) and 4-dimethylaminopyridine (DMAP).
Ye-fei Yuan, Xiang-yu Hu, Ying He, Jia-gang Deng   +3 more
doaj   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Model‐Based Bayesian Optimization for Organic Photovoltaics: Combining Bayesian Optimization With Physical Domain Knowledge

Advanced Energy Materials, EarlyView.
Integration of a physical solar cell model into Bayesian optimization is performed using the Knowledge Gradient acquisition function to balance exploration and exploitation. Experimental validation on the PTQ10:BTP‐eC9 material system and statistical validation on an OPV benchmark function show that the model‐based approach outperforms conventional ...
Leonard Christen, Thomas Kirchartz
wiley   +1 more source

Heat Transfer Fluids as Co‐Diluents in Localized High‐Concentration Electrolytes for High‐Rate Lithium Metal Batteries With Enhanced Safety

Angewandte Chemie International Edition, EarlyView.
Two fluorinated ethers, commonly used as heat‐transfer fluids, are explored as co‐diluents in localized high‐concentration electrolytes (LHCEs) for lithium metal‐based batteries. The best‐performing ternary diluent blend boosts ion mobility and cuts overvoltages, thereby improving Coulombic efficiency and cycle life at ≥1 mA cm−2 in zero‐excess pouch ...
Dominik Weintz, Adil Aboobacker, Andrew Dopilka, Felix Pfeiffer, Anne Hockmann, Uta Rodehorst, Christian Wölke, Monika Schönhoff, Robert Kostecki, Diddo Diddens, Martin Winter, Isidora Cekic‐Laskovic   +11 more
wiley   +1 more source

Am Rhein

, 2012
Source: Anastasius Grün: Gesammelte Werke, Herausgegeben von Ludwig August Frankl, Band 1–4, Berlin: Grote, 1907.
  +8 more sources