Results 21 to 30 of about 126,869 (297)

Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway

Journal of Experimental & Clinical Cancer Research, 2019
Background Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Emerging evidence suggests that rhein has significant antitumor effects, supporting its potential use as an antitumor agent.
Lehe Yang, Shichong Lin, Yanting Kang, Youqun Xiang, Lingyuan Xu, Jifa Li, Xuanxuan Dai, Guang Liang, Xiaoying Huang, Chengguang Zhao   +9 more
doaj   +1 more source

Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing. [PDF]

, 2019
Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg), with the recent development and distribution of a point-of-care lateral ...
Beyene, T, Boulware, DR, Katende, A, Letang, E, Rajasingham, R, Wake, RM   +5 more
core   +1 more source

Stable Synapse‐Like Memory Switching in N‐Heterocyclic Carbene Monolayers

Angewandte Chemie, EarlyView.
We report a redox‐active N‐heterocyclic carbene (NHC) monolayer showing synapse‐like behavior via proton‐coupled electron transfer (PCET). These quinone‐functionalized NHCs form dense self‐assembled monolayers and highly stable molecular junctions. Bias‐driven PCET switches quinone/hydroquinone states, producing reversible hysteresis and spike‐timing ...
Ankita Das, Alessandro Borrini, Christian Gutheil, Björn Braunschweig, Billura Shakhayeva, Georgios Katsoukis, Ab F. Nieuwenhuis, Raka Ahmed, Susanne Leitherer, Gemma C. Solomon, Frank Glorius, Christian A. Nijhuis   +11 more
wiley   +2 more sources

Antiviral Activity of Rhein against Enterovirus 71 through Inhibiting Viral Replication and Stability

Journal of Medical Sciences
Background Enterovirus 71 (EV71) is one of the most prevalent pathogens responsible for hand, foot, and mouth disease in the Asia-Pacific region. Severe EV71 infections can be fatal in children under the age of 5. As of now, there are no proven anti-EV71
Zheng-Zong Lai, Hung Chen Yang, Yen-Mei Lee   +2 more
doaj   +1 more source

Development of an Enzyme-Linked Immunosorbent Assay Method for the Detection of Rhein in Rheum officinale

International Journal of Analytical Chemistry, 2020
Rhein is an important quality-control marker of Rheum officinale. The aim of this study was to develop an indirect competitive enzyme-linked immunosorbent assay (icELISA) for rhein detection, which acts as a powerful tool for quality control and proper ...
Min Chen, Tie-Gui Nan, Jie Xin, Li Cui, Bo Zhang, Xiao Wang, Bao-Min Wang   +6 more
doaj   +1 more source

Anthraquinone Rhein Exhibits Antibacterial Activity against Staphylococcus aureus

Applied Sciences, 2022
Staphylococcus aureus (S. aureus) represents an important pathogen of clinical relevance, causing a wide variety of symptoms. The broad distribution of multidrug-resistant strains necessarily demands new antibacterial agents for the treatment of S ...
Federica Dell’Annunziata, Veronica Folliero, Francesca Palma, Valeria Crudele, Emiliana Finamore, Giuseppina Sanna, Aldo Manzin, Anna De Filippis, Massimiliano Galdiero, Gianluigi Franci   +9 more
doaj   +1 more source

On the Role of Reaction Current Distribution to Attain Competitive Solid‐State Batteries

Angewandte Chemie, EarlyView.
We conducted a case study on reaction current inhomogeneities when increasing areal loadings and charging rates in NCM‐argyrodite composite cathodes for solid‐state batteries. Using a combination of cycling experiments and operando high‐energy X‐ray diffraction, we show that employing faster conducting Li5.5PS4.5Cl1.5 instead of Li6PS5Cl as catholyte ...
Johannes Hartel, Lukas Ketter, Eva Schlautmann, Erik Šimon, Karol Végsö, Poongodi Ayyanusamy, Tim Bernges, Peter Siffalovic, Wolfgang G. Zeier   +8 more
wiley   +2 more sources

Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice

Communications Biology
Rhein, a component derived from rhubarb, has been proven to possess anti-inflammatory properties. Here, we show that rhein mitigates obesity by promoting adipose tissue thermogenesis in diet-induced obese mice.
Ruo-Nan Zhou, Zi-Wei Zhu, Ping-Yuan Xu, Li-Xuan Shen, Ziwei Wang, Ying-Ying Xue, Ying-Ying Xiang, Yue Cao, Xi-Zhong Yu, Juan Zhao, Yu Jin, Jing Yan, Qin Yang, Peng-Hua Fang, Wen-Bin Shang   +14 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Atomic‐Scale Understanding of Selectivity Control in Nitrate Reduction on Cu(100) Under Acidic and Alkaline Conditions

Angewandte Chemie, EarlyView.
A combination of ab initio molecular dynamics simulations and density functional theory calculations clarifies the pH‐dependent origin of the selectivity of nitrate reduction on Cu(100). ABSTRACT We investigate the nitrate reduction reaction (NO3 RR) on the Cu(100) surface using grand‐canonical density functional theory (GC‐DFT) under constant ...
Ebrahim Tayyebi, Kai S. Exner
wiley   +2 more sources