Results 21 to 30 of about 14,550 (256)
Journal of Medical SciencesBackground Enterovirus 71 (EV71) is one of the most prevalent pathogens responsible for hand, foot, and mouth disease in the Asia-Pacific region. Severe EV71 infections can be fatal in children under the age of 5. As of now, there are no proven anti-EV71
Zheng-Zong Lai +2 more
doaj +1 more source
Rhein targets macrophage SIRT2 to promote adipose tissue thermogenesis in obesity in mice
Communications BiologyRhein, a component derived from rhubarb, has been proven to possess anti-inflammatory properties. Here, we show that rhein mitigates obesity by promoting adipose tissue thermogenesis in diet-induced obese mice.
Ruo-Nan Zhou +14 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Objectives: The interaction between the components of traditional Chinese medicine (TCM) is an important basis for their synergy. Rhein and curcumin exert various pharmacological activities, including anti-tumour, anti-inflammatory, antioxidant, anti ...
Xiaoying He +7 more
doaj +1 more source
Rhein-Entsprungenes : Mythologie in Hölderlins Hymne „Der Rhein”
, 2006 Im Medium der Kunst und im Medium der Philosophie eröffnen Marion T. Mentges, Robert Schwarz und Stephan Grätzel die Mythologie in Hölderlins Hymne „Der Rhein” und ermöglichen dem Betrachter und Leser neue, ungeahnte Gesichtspunkte und Blickwinkel, die zur Reflexion über den Mythos Rhein anregen.
Grätzel, Stephan +2 more
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway
Journal of Experimental & Clinical Cancer Research, 2019 Background Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Emerging evidence suggests that rhein has significant antitumor effects, supporting its potential use as an antitumor agent.
Lehe Yang +9 more
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International Journal of Analytical Chemistry, 2020 Rhein is an important quality-control marker of Rheum officinale. The aim of this study was to develop an indirect competitive enzyme-linked immunosorbent assay (icELISA) for rhein detection, which acts as a powerful tool for quality control and proper ...
Min Chen +6 more
doaj +1 more source
Anthraquinone Rhein Exhibits Antibacterial Activity against Staphylococcus aureus
Applied Sciences, 2022 Staphylococcus aureus (S. aureus) represents an important pathogen of clinical relevance, causing a wide variety of symptoms. The broad distribution of multidrug-resistant strains necessarily demands new antibacterial agents for the treatment of S ...
Federica Dell’Annunziata +9 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source