Results 11 to 20 of about 14,550 (256)

Rhein suppresses African swine fever virus replication in vitro via activating the caspase-dependent mitochondrial apoptosis pathway

Virus Research, 2023
African swine fever (ASF) is a virulent infectious diseases of pigs caused by the African swine fever virus (ASFV) that can spread widely and cause high fatality rates.
Zebu Song, Yang Chen, Hao Chang, Yanchen Guo, Qi Gao, Zhi Wei, Lang Gong, Guihong Zhang, ZeZhong Zheng   +8 more
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Rhein ameliorates transverse aortic constriction-induced cardiac hypertrophy via regulating STAT3 and p38 MAPK signaling pathways

Frontiers in Pharmacology, 2022
The progression from compensatory hypertrophy to heart failure is difficult to reverse, in part due to extracellular matrix fibrosis and continuous activation of abnormal signaling pathways. Although the anthraquinone rhein has been examined for its many
Run-Jing Li, Jia-Jia Xu, Zheng-Hao Zhang, Min-Wei Chen, Shi-Xiao Liu, Cui Yang, Yan-Ling Li, Ping Luo, Yi-Jiang Liu, Rong Tang, Zhong-Gui Shan   +10 more
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Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat

Journal of Pharmacy and Pharmacology, 1988
Abstract After single intracaecal administration of [14C]rhein (25 mg kg−1) and [14C]rhein anthrone (20 mg kg−1) to rats, the summated recovery rates of 14C after five days were in urine 37(±8.3)% and 2.8(±0.4)% and in faeces 53(±9.5)% and 95 (±10.1)%, respectively.
P, De Witte, J, Lemli
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Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway

Brazilian Journal of Medical and Biological Research, 2012
Rhein is a primary anthraquinone found in the roots of a traditional Chinese herb, rhubarb, and has been shown to have some anticancer effects. The aim of the present study was to investigate the effect of rhein on the apoptosis of the human gastric ...
Yiwen Li, Yuqing Xu, Bo Lei, Wenxiu Wang, Xin Ge, Jingrui Li   +5 more
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Intervention and mechanism research of rhein on Staphylococcus xylosus biofilms

Siliao yanjiu, 2022
The minimum inhibitory concentration (MIC) of rhein was determined by standard microdilution method, and crystal violet staining method was used to investigate the intervention of rhein on the biofilm formation of S. xylosus. The S.
Ting-ting LÜ, Zhong-bin ZHANG, Shuang HE, Jin-xin MA, Wen-ya DING   +4 more
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The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis

Frontiers in Immunology, 2022
BackgroundRhubarb is an important traditional Chinese medicine, and rhein is one of its most important active ingredients. Studies have found that rhein can improve ulcerative colitis by regulating gut microbes, but there are few reports on its effects ...
Shuhui Liu, Ruiying Yin, Ziwei Yang, Feili Wei, Jianhua Hu   +4 more
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Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways. [PDF]

PLoS ONE, 2018
Rhein, an anthraquinone compound existing in many traditional herbal medicines, has anti-inflammatory, antioxidant, antitumor, antiviral, hepatoprotective, and nephroprotective activities, but its anti-influenza A virus (IAV) activity is ambiguous.
Qian-Wen Wang, Yun Su, Jiang-Tao Sheng, Li-Ming Gu, Ying Zhao, Xiao-Xuan Chen, Cheng Chen, Wei-Zhong Li, Kang-Sheng Li, Jian-Ping Dai   +9 more
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Rhein Protects Against Severe Acute Pancreatitis In vitro and In vivo by Regulating the JAK2/STAT3 Pathway

Frontiers in Pharmacology, 2022
Rhein is widely used in inflammation treatment in China, but its effects on severe acute pancreatitis (SAP) have not been studied closely. This study investigated rhein’s protective effects against SAP using in vitro and in vivo models to determine ...
Xiaofang Yang, Huan Geng, Lijiao You, Lin Yuan, Jialei Meng, Yuhui Ma, Xuelian Gu, Ming Lei   +7 more
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Rhein attenuates obesity-related glomerulopathy by inhibiting the P2X7R/NLRP3 inflammasome pathway and protecting podocytes [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): To investigate the renoprotective effects of Rhein in obesity-related glomerulopathy (ORG) by inhibiting the P2X7 receptor (P2X7R)/NOD-like receptor protein 3 (NLRP3) inflammasome pathway.Materials and Methods: ORG was induced in C57BL/6J ...
Lifang Wei, Jinwen Zhang, Liangding Dou, Xiaoxin Wu, Minmin Xu, Jinxia Ye, Yanyan Yang, Yongxing Zhang, Shaojian Xiao   +8 more
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Simultaneous Estimation of Rhein and Aloe-Emodin in Traditional and Ultrasound-Based Extracts of Rheum palmatum L. (Rhubarb) Using Sustainable Reverse-Phase and Conventional Normal-Phase HPTLC Methods

Agronomy, 2022
The greenness indices of literature analytical procedures for the simultaneous measurement of rhein and aloe-emodin have not been determined. As a consequence, the first goal of this study was to design and validate a sensitive and sustainable reverse ...
Mohammed H. Alqarni, Prawez Alam, Faiyaz Shakeel, Aftab Alam, Mohammad A. Salkini, Magdy M. Muharram   +5 more
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