Results 31 to 40 of about 76,583 (247)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway

Journal of Experimental & Clinical Cancer Research, 2019
Background Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Emerging evidence suggests that rhein has significant antitumor effects, supporting its potential use as an antitumor agent.
Lehe Yang, Shichong Lin, Yanting Kang, Youqun Xiang, Lingyuan Xu, Jifa Li, Xuanxuan Dai, Guang Liang, Xiaoying Huang, Chengguang Zhao   +9 more
doaj   +1 more source

Development of an Enzyme-Linked Immunosorbent Assay Method for the Detection of Rhein in Rheum officinale

International Journal of Analytical Chemistry, 2020
Rhein is an important quality-control marker of Rheum officinale. The aim of this study was to develop an indirect competitive enzyme-linked immunosorbent assay (icELISA) for rhein detection, which acts as a powerful tool for quality control and proper ...
Min Chen, Tie-Gui Nan, Jie Xin, Li Cui, Bo Zhang, Xiao Wang, Bao-Min Wang   +6 more
doaj   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source

A Descriptor for Non‐Arrhenius Ion Transport Enables Design of Sulfide Superionic Conductors

Angewandte Chemie, EarlyView.
A curated database of sulfide electrolytes reveals widespread non‐Arrhenius ion transport. Meyer–Neldel deviation (MND) quantifies this behavior, distinguishes low‐conductivity and superionic regimes, and guides composition screening. An experimentally validated candidate exhibits room‐temperature conductivity of 7.21 mS cm−1, an apparent activation ...
Han Zhou, Xiaoxuan Chen, Hermann Tempel, Yong Yang, Boryann Liaw, Shicheng Yu, Rüdiger‐A. Eichel   +6 more
wiley   +2 more sources

Fe(III)/peroxymonosulfate oxidation system for the degradation of rhein, a toxic component abundance in rhubarb residue

Ecotoxicology and Environmental Safety
Rhubarb is widely used in health care, but causing a great amount of rhein-containing herbal residue. Rhein with several toxicities might pollute environment, damage ecology and even hazard human health if left untreated.
Zhong-Wei Yao, Xiang-Ling Qin, Qi-Long Li, Ling-Hui Pan, Wei-Feng Hu, Su-Ping Ling, Hui Liu, He Zhu   +7 more
doaj   +1 more source

Anthraquinone Rhein Exhibits Antibacterial Activity against Staphylococcus aureus

Applied Sciences, 2022
Staphylococcus aureus (S. aureus) represents an important pathogen of clinical relevance, causing a wide variety of symptoms. The broad distribution of multidrug-resistant strains necessarily demands new antibacterial agents for the treatment of S ...
Federica Dell’Annunziata, Veronica Folliero, Francesca Palma, Valeria Crudele, Emiliana Finamore, Giuseppina Sanna, Aldo Manzin, Anna De Filippis, Massimiliano Galdiero, Gianluigi Franci   +9 more
doaj   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

AErOmAt Abschlussbericht

, 2020
Das Projekt AErOmAt hatte zum Ziel, neue Methoden zu entwickeln, um einen erheblichen Teil aerodynamischer Simulationen bei rechenaufwändigen Optimierungsdomänen einzusparen.
Meng, Jakob, Asteroth, Alexander, Priesnitz, Andreas, Gaier, Adam, Hagg, Alexander, Reith, Dirk, Prochnau, Lea   +6 more
core   +1 more source