Results 1 to 10 of about 3,030 (150)

Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic Potential

Biomolecules, 2019
Chrysophanol is a unique anthraquinone having broad-spectrum therapeutic potential along with ecological importance. It is the first polyketide that has been reported to be biosynthesized in an organism-specific manner. The traditional Chinese and Korean
Ravindra Kharwar, Leonardo Fraceto, Surya Sudheer   +2 more
exaly   +4 more sources

Anti-Inflammatory Activity of Chrysophanol through the Suppression of NF-kB/Caspase-1 Activation in Vitro and in Vivo

Molecules, 2010
Chrysophanol is a member of the anthraquinone family and has multiple pharmacological effects, but the exact mechanism of the anti-inflammatory effects of chrysophanol has yet to be thoroughly elucidated.
Jae-Young Um, Seung-Heon Hong
exaly   +4 more sources

Chrysophanol-Induced Autophagy Disrupts Apoptosis via the PI3K/Akt/mTOR Pathway in Oral Squamous Cell Carcinoma Cells

Medicina, 2022
Background and Objectives: Natural products are necessary sources for drug discovery and have contributed to cancer chemotherapy over the past few decades. Furthermore, substances derived from plants have fewer side effects.
Dan-Bi Park, Bong-Soo Park, Hae-Mi Kang, Jung-Han Kim, In-Ryoung Kim   +4 more
doaj   +2 more sources

Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines

Life, 2021
The tumor microenvironment plays a critical role in the control of metastasis. The epithelial–mesenchymal transition (EMT) is strongly associated with tumor metastasis, and consists of several protein markers, including E-cadherin and vimentin.
Po-Chih Hsu, Yi-Hsuan Chen, Ching-Feng Cheng, Chan-Yen Kuo, Huey-Kang Sytwu   +4 more
doaj   +3 more sources

Chrysophanol Attenuates Manifestations of Immune Bowel Diseases by Regulation of Colorectal Cells and T Cells Activation In Vivo

Molecules, 2021
Inflammatory bowel disease (IBD) is an immune disorder that develops due to chronic inflammation in several cells. It is known that colorectal and T cells are mainly involved in the pathogenesis of IBD. Chrysophanol is an anthraquinone family member that
Hyun-Su Lee, Gil-Saeng Jeong
doaj   +2 more sources

Ultrastructural Changes of Sphaerotheca fuliginea (Schlechtend.:Fr.) Pollacci in Cucumber After Treated by Chrysophanol

Journal of Integrative Agriculture, 2012
Chrysophanol (1,8-dihydroxy-3-methylanthraquinone) is a free anthraquinone compound and a secondary metabolite of medicinal plant rhubarb. Chrysophanol has been reported to have both protective and curative activity against Sphaerotheca fuliginea ...
Hong-min REN, Fan FAN, Ke-qiang CAO
doaj   +2 more sources

Nephroprotective Role of Chrysophanol in Hypoxia/Reoxygenation-Induced Renal Cell Damage via Apoptosis, ER Stress, and Ferroptosis

Biomedicines, 2021
Acute kidney injury (AKI) is caused by hypoxia-reoxygenation (H/R), which is a kidney injury produced by a variety of causes, resulting in the remaining portion of the kidney function being unable to maintain the balance for performing the tasks of waste
Chih-Hung Lin, Han-Fang Tseng, Po-Chun Hsieh, Valeria Chiu, Ting-Yun Lin, Chou-Chin Lan, I-Shiang Tzeng, Huan-Nung Chao, Chia-Chen Hsu, Chan-Yen Kuo   +9 more
doaj   +2 more sources

Chrysophanol Suppresses Cell Growth via mTOR/PPAR-α Regulation and ROS Accumulation in Cultured Human Tongue Squamous Carcinoma SAS Cells

Current Issues in Molecular Biology, 2022
Oral cancer, a type of head and neck cancer, can pose a significant risk of death unless diagnosed and treated early. Alternative treatments are urgently needed owing to the high mortality rate, limitations of conventional treatments, and many ...
Po-Chih Hsu, Chia-Chen Hsu, Yi-Jan Hsia, Chan-Yen Kuo   +3 more
doaj   +2 more sources

Comparative Phytochemical Analysis of Five South African Bulbine Species Using Chromatography‐Based Methods [PDF]

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Comprehensive chromatographic and chemometric profiling of five medicinal South African Bulbine species across leaves, rhizomes, and roots reveals 73 metabolites, including species‐specific phenylanthraquinones, flavonoids, and anthocyanins, that serve as reliable chemical markers for species authentication.
Ramoagi T. Segone, Maxleene Sandasi, Efficient Ncube, Weiyang Chen, Bharathi Avula, Kumar Katragunta, Ikhlas A. Khan, Alvaro M. Viljoen   +7 more
wiley   +2 more sources

Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis

Journal of Pharmacological Sciences, 2020
Hepatitis B virus X protein (HBx) and hepatic stellate cells (HSCs) are critical for liver fibrosis development. Anti-fibrosis occurs via reversion to quiescent-type HSCs or clearance of HSCs via apoptosis or ferroptosis.
Chan-Yen Kuo, Valeria Chiu, Po-Chun Hsieh, Chun-Yen Huang, S. Joseph Huang, I-Shiang Tzeng, Fu-Ming Tsai, Mao-Liang Chen, Chien-Ting Liu, Yi-Ru Chen   +9 more
doaj   +2 more sources