Results 21 to 30 of about 3,030 (150)

Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice [PDF]

Frontiers in Pharmacology
BackgroundStress is among the most common comorbid conditions with epilepsy and a strong factor in the pathophysiology of seizures. An imbalance in neuronal circuits causes recurrent unprovoked seizures in epilepsy. Dysregulation of BDNF/VEGF expression,
Jehan Zeb Khan, Syeda Rida Zainab, Mujeeb Ur Rehman, Muhammad Abid, Fawad Ali Shah, Najeeb Ur Rehman, Muhammad Khalid Tipu   +6 more
doaj   +2 more sources

Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury [PDF]

Frontiers in Pharmacology
ObjectiveSepsis-associated acute kidney injury (SA-AKI) is a frequent and severe complication in septic patients. This study combines network pharmacology with in vitro and in vivo experiments to preliminarily investigate the protective effect of ...
Xuan Gou, Xuan Gou, Wei Zhang, Wei Zhang, Lele Wang, Lele Wang, Caixia Tan, Caixia Tan, Hong Wei, Hong Wei, Xinmin Wang, Xinmin Wang, Le Zhang, Le Zhang, Le Zhang   +14 more
doaj   +2 more sources

Chrysophanol‐induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential

Environmental Toxicology, 2014
[[abstract]]Chrysophanol (1,8-dihydroxy-3-methylanthraquinone) is one of the anthraquinone compounds, and it has been shown to induce cell death in different types of cancer cells. The effects of chrysophanol on human lung cancer cell death have not been
Jai-Sing Yang, Po-Yuan Chen
exaly   +1 more source

Synthesis of antioxidative anthraquinones as potential anticancer agents

Bibechana, 2021
Antioxidant and antibacterial activities of natural anthraquinones namely chrysophanol (1) and emodin (2), and synthesized anthraquinones viz. 2-methylanthraquinone (3), anthraquinone (4), 2-bromoanthraquinone (5), rubiadin (6), chrysophanol diacetate ...
Richa K. Gupta, Ganesh M. S. Thakuri, Gan B Bajracharya, Ram Narayan Jha   +3 more
doaj   +3 more sources

Chrysophanol Exerts Anti-inflammatory Activity by Targeting Histone Deacetylase 3 Through the High Mobility Group Protein 1-Nuclear Transcription Factor-Kappa B Signaling Pathway in vivo and in vitro

Frontiers in Bioengineering and Biotechnology, 2021
Chrysophanol (Chr) is the main monomer isolated from Rheum rhabarbarum. This study aimed to identify the potential in vitro and in vivo cytoprotective effects of Chr on lipopolysaccharide (LPS)-triggered acute lung injury (ALI).
Quan Wen, Quan Wen, Ngaikeung Lau, Huandi Weng, Peng Ye, Shaohui Du, Chun Li, Jianping Lv, Hui Li   +8 more
doaj   +1 more source

One-pot Synthesis of N-doped Reduced Graphene Oxide Decorated with Au-Pd@Au Alloy Nanodendrites for Electrochemical Detection of Chrysophanol

International Journal of Electrochemical Science, 2020
We demonstrate for the first time a new one-step effective route for the preparing of N-doped reduced graphene oxide loading with Au-Pd@Au (N-rGO-Au-Pd@Au) alloy nanodendrites. Then the prepared N-rGO-Au-Pd@Au alloy nanodendrites were used to fabricate a
Ling Shi, Ze-Feng Wang, Na Wu, Gao-Zhang Gou, Xian-Lan Chen, Guang-Ming Yang, Wei Liu   +6 more
doaj   +1 more source

Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation

Frontiers in Physiology, 2021
Cisplatin (CDDP) is one of the most frequently prescribed chemotherapy medications. However, its nephrotoxicity which often leads to acute kidney injury (AKI), greatly limits its clinical application.
Siqing Ma, Siqing Ma, Siqing Ma, Siqing Ma, Heng Xu, Weihua Huang, Weihua Huang, Weihua Huang, Weihua Huang, Yongchao Gao, Yongchao Gao, Yongchao Gao, Yongchao Gao, Honghao Zhou, Honghao Zhou, Honghao Zhou, Honghao Zhou, Xiong Li, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang   +21 more
doaj   +1 more source

In Vitro, Molecular Docking and In Silico ADME/Tox Studies of Emodin and Chrysophanol against Human Colorectal and Cervical Carcinoma

Pharmaceuticals, 2022
Anthraquinones (AQs) are present in foods, dietary supplements, pharmaceuticals, and traditional treatments and have a wide spectrum of pharmacological activities. In the search for anti-cancer drugs, AQ derivatives are an important class. In this study,
Wasim Ahmad, Mohammad Azam Ansari, Abdulrhman Alsayari, Dalia Almaghaslah, Shadma Wahab, Mohammad N. Alomary, Qazi Mohammad Sajid Jamal, Firdos Alam Khan, Abuzer Ali, Prawez Alam, Abozer Y. Elderdery   +10 more
doaj   +1 more source

Chrysophanol Induced Glioma Cells Apoptosis via Activation of Mitochondrial Apoptosis Pathway

, 2021
Glioma is a common intracranial tumor originated from neuroglia cell. Chrysophanol is an anthraquinone derivative proved to exert anticancer effects in various cancers. This paper investigated the effect and mechanism of chrysophanol in glioma.
Wenjian Zhan (11431434), Sunil Rauniyar (11431431), Shaogan Ji (11431437), Jia Gu (1518259), Yan Wang (15435), Chengkun Ye (6324113), Guanzheng Liu (583993)   +6 more
core   +1 more source

The prospects and potential of the horticultural and pharmacological medicinal herb senna (Cassia angustifolia Vahl.): A review

Technology in Horticulture, 2023
The dried leaves and pods of Cassia L., a member of the Caesalpinioideae subfamily of the Fabaceae family and the Cassiinae sub-tribe are called 'senna drug'.
Raj Kishori Lal, Chandan Singh Chanotiya, Ashish Kumar   +2 more
doaj   +1 more source