Results 11 to 20 of about 4,551 (194)

Novel protein photocleavers: Chrysophanol and pachybasin

Journal of Photochemistry and Photobiology, 2020
This study investigates the photocleavage activity of two anthraquinone derivatives isolated from T. harzianum ETS 323, chrysophanol and pachybasin, upon proteins.
Kou-Cheng Peng, Kun-Che Chang, Shyue-Chu Ke, JunRu Chen, Shu-Ying Liu   +4 more
doaj   +4 more sources

The pharmacological properties of chrysophanol, the recent advances.

Biomedicine & Pharmacotherapy, 2020
As a universal Chinese medicine, Rhei Radix et Rhizoma was used for centuries in different fields including pharmaceutical, health care and cosmetics. Chrysophanol (Chr) is one of the most important anthraquinone components isolated from plants of the ...
Siyu Su, Jiasi Wu, Yue Gao, Yu Luo, Dong Yang, Ping Wang   +5 more
semanticscholar   +3 more sources

Anti-Inflammatory Activity of Chrysophanol through the Suppression of NF-kB/Caspase-1 Activation in Vitro and in Vivo

Molecules, 2010
Chrysophanol is a member of the anthraquinone family and has multiple pharmacological effects, but the exact mechanism of the anti-inflammatory effects of chrysophanol has yet to be thoroughly elucidated.
Jae-Young Um, Seung-Heon Hong, Kim Su-Jin   +2 more
exaly   +3 more sources

Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines

Life, 2021
The tumor microenvironment plays a critical role in the control of metastasis. The epithelial–mesenchymal transition (EMT) is strongly associated with tumor metastasis, and consists of several protein markers, including E-cadherin and vimentin.
Po-Chih Hsu, Yi-Hsuan Chen, Ching-Feng Cheng, Chan-Yen Kuo, Huey-Kang Sytwu   +4 more
doaj   +2 more sources

Chrysophanol Suppresses Cell Growth via mTOR/PPAR-α Regulation and ROS Accumulation in Cultured Human Tongue Squamous Carcinoma SAS Cells

Current Issues in Molecular Biology, 2022
Oral cancer, a type of head and neck cancer, can pose a significant risk of death unless diagnosed and treated early. Alternative treatments are urgently needed owing to the high mortality rate, limitations of conventional treatments, and many ...
Po-Chih Hsu, Chia-Chen Hsu, Yi-Jan Hsia, Chan-Yen Kuo   +3 more
doaj   +2 more sources

In Vitro, Molecular Docking and In Silico ADME/Tox Studies of Emodin and Chrysophanol against Human Colorectal and Cervical Carcinoma

Pharmaceuticals, 2022
Anthraquinones (AQs) are present in foods, dietary supplements, pharmaceuticals, and traditional treatments and have a wide spectrum of pharmacological activities. In the search for anti-cancer drugs, AQ derivatives are an important class. In this study,
Wasim Ahmad, Mohammad Azam Ansari, Abdulrhman Alsayari, Dalia Almaghaslah, Shadma Wahab, Mohammad N. Alomary, Qazi Mohammad Sajid Jamal, Firdos Alam Khan, Abuzer Ali, Prawez Alam, Abozer Y. Elderdery   +10 more
doaj   +2 more sources

Protective effects and mechanism of chrysophanol against age-related osteoporosis in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): This study aimed to investigate the protective effect and underlying mechanism of chrysophanol (CPH) on senile osteoporosis (OP) in rats.
Qing Lu, Chenxi Zhang, Lixia Ma, Xiaoyao Yu, Gan Zhang, Dagui Chen, Fusheng Shang   +6 more
doaj   +2 more sources

Cytotoxic and apoptotic potential of gemini-chrysophanol nanoparticles against human colorectal cancer HCT-116 cell lines

BMC Pharmacology and Toxicology, 2022
Background Colorectal cancer is among the most common cancers and accounts for nearly 9% of all cancers in the world. Chrysophanol is a naturally occurring anthraquinone exerts a number of pharmacological activities such as anti-inflammation, anti ...
Alaadin M. Naqishbandi
doaj   +2 more sources

Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury [PDF]

Frontiers in Pharmacology
ObjectiveSepsis-associated acute kidney injury (SA-AKI) is a frequent and severe complication in septic patients. This study combines network pharmacology with in vitro and in vivo experiments to preliminarily investigate the protective effect of ...
Xuan Gou, Xuan Gou, Wei Zhang, Wei Zhang, Lele Wang, Lele Wang, Caixia Tan, Caixia Tan, Hong Wei, Hong Wei, Xinmin Wang, Xinmin Wang, Le Zhang, Le Zhang, Le Zhang   +14 more
doaj   +2 more sources

Comparative Phytochemical Analysis of Five South African Bulbine Species Using Chromatography-Based Methods. [PDF]

Chem Biodivers
Comprehensive chromatographic and chemometric profiling of five medicinal South African Bulbine species across leaves, rhizomes, and roots reveals 73 metabolites, including species‐specific phenylanthraquinones, flavonoids, and anthocyanins, that serve as reliable chemical markers for species authentication.
Segone RT, Sandasi M, Ncube E, Chen W, Avula B, Katragunta K, Khan IA, Viljoen AM.   +7 more
europepmc   +2 more sources