Physcion Protects Against Ethanol-Induced Liver Injury by Reprogramming of Circadian Clock [PDF]
Frontiers in Pharmacology, 2020 The circadian clock plays a key role in our daily physiology and metabolism. Alcohol consumption disrupts the circadian rhythm of metabolic genes in the liver; however, the potential contribution of circadian clock modulation to alcoholic liver disease ...
Youli Yao +8 more
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Gut microbiota and HMGB1/NLRP3/GSDMD inflammasome-dependent pyroptosis: mechanisms by physcion ameliorates alcoholic liver fibrosis [PDF]
Frontiers in PharmacologyAlcoholic liver fibrosis (ALF) developed from long-term excessive alcohol consumption, which causes inflammatory reactions, lipid accumulation and cirrhosis.
Ting Bai +7 more
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Drug Design, Development and Therapy, 2021 Xiaobo Dong,* Lei Wang,* Guangrong Song, Xu Cai, Wenxin Wang, Jiaqi Chen, Gesheng Wang The Third Department of Encephalopathy, Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, People’s Republic of China*These authors ...
Dong X +6 more
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Association of Physcion and Chitosan Can Efficiently Control Powdery Mildew in Rosa roxburghii
Antibiotics, 2022 Powdery mildew is an extremely serious disease of all Rosa roxburghii production regions in China and frequently causes 30~40% of economic losses. Natural products are considered excellent alternatives to chemical fungicides.
Cheng Zhang +3 more
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Antitumor activity of physcion 8-o-β-glucopyranoside against cervical cancer by induction of apoptosis [PDF]
Pharmacological Reports, 2016 Purpose: To investigate the antitumor activity of physcion8-O-β-glucopyranoside (PSG) against cervical cancer, as well as its mechanisms.Methods: The anti-proliferative effects of PSG on HeLa cells were determined by CCK-8 assay and the half maximal ...
Yuanqi He +3 more
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Physcion Induces Hemolysis and Premature Phosphatidylserine Externalization in Human Erythrocytes
Biological and Pharmaceutical Bulletin, 2021 The prevalence of cancer-associated anemia (CIA) is high, and the mechanisms governing its development remain poorly understood. Eryptosis, the suicidal cell death of red blood cells (RBCs), may account for CIA as it is triggered by clinically approved chemotherapeutics including cisplatin and paclitaxel. Physcion (PSN), an anthraquinone extracted from
Maaged Akiel +14 more
semanticscholar +5 more sources
Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities [PDF]
Current Drug Targets, 2021 Nature has provided prodigious reservoirs of pharmacologically active compounds for drug development since times. Physcion and physcion 8-O-β-D-glucopyranoside (PG) are bioactive natural anthraquinones which exert anti-inflammatory and anticancer properties with minimum or no adverse effects.
Shah, MA +11 more
semanticscholar +5 more sources
Physcion, a novel anthraquinone derivative against Chlamydia psittaci infection
Veterinary Microbiology, 2023 Physcion, a natural anthraquinone derivative, has been reported to exert remarkable antibacterial activities against Staphylococcus aureus,Staphylococcus epidermidis and Pseudomonas aeruginosa. However, it is not fully illustrated as anti-Chlamydia substance.
Xinyi Liu +5 more
openaire +3 more sources
Scientific Reports, 2022 The use of biopesticides has gradually become essential to ensure food security and sustainable agricultural production. Nevertheless, the use of single biopesticides is frequently suboptimal in agricultural production given the diversity of biotic and ...
Jingchong Li +6 more
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Physcion effectively mitigates ovariectomy-induced osteoporosis in mice
Medicine in Drug Discovery, 2020 Aims: In this study, an ovariectomized mouse model was used to investigate the therapeutic effect of physcion on bone loss caused by estrogen deficiency.
Yun-Ho Hwang +3 more
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