Results 71 to 80 of about 1,189,976 (269)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The effect of space travel on human reproductive health: a systematic review

npj Microgravity
With increasing possibilities of multi-year missions in deep space, colonizing other planets, and space tourism, it is important to investigate the effects of space travel on human reproduction. This study aimed to systematically review and summarize the
Marta Gimunová, Ana Carolina Paludo, Martina Bernaciková, Julie Bienertova-Vasku   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

The Role Of Digital Governance In The Success Of Digital Transformation In The Institute Of Physical And Sports Education Of The University Of Algiers 3

مجلة العلوم و التكنولوجية للنشاطات البدنية و الرياضية
The study aimed to highlight the role of digital governance in the success of digital transformation in Algerian universities and the purpose of the study was to know that digital governance played a role in the success of digital transformation, The ...
Tahiri Mohamed El Amine, Ladjal Yahia
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Analysis of intermittent training and small-sided games training methods and their impact on explosive power of the lower limbs in U19 soccer players.

مجلة العلوم و التكنولوجية للنشاطات البدنية و الرياضية
The study aims to identify the effectiveness of a proposed training program using two methods: Intermittent training and small-sided games training on developing explosive power in soccer players under 19 years old.
Messai Oussama, Ferahtia Sabira, Mebarka Sonia Toumi   +2 more
doaj   +1 more source

Physical activity promotion [PDF]

British Journal of General Practice, 2010
Davies and Garbutt wrote an important and commendable editorial on exercise prescription;1 however, there are some fundamental issues raised requiring clarification and further consideration. First, when measured objectively, a staggering 95% of the adult population (UK and US) do not meet the minimum recommended levels of physical activity to confer ...
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Effect Of A Proposed Training Programme To Enhance Health Related Components Of Physical Fitness Of The Secondary School Male Students (17-18 Years Old)

مجلة العلوم و التكنولوجية للنشاطات البدنية و الرياضية
This study aims at identifying the effect of a proposed training program on improving the components of the physical fitness related to the health of the secondary school students.
Redouane Boubekeur, Laidoudi Abdelhalim
doaj   +1 more source