Results 91 to 100 of about 6,226,403 (313)

Effects of beetroot juice supplementation on intermittent high-intensity exercise efforts

Journal of the International Society of Sports Nutrition, 2018
Beetroot juice contains high levels of inorganic nitrate (NO3 −) and its intake has proved effective at increasing blood nitric oxide (NO) concentrations.
Raúl Domínguez, José Luis Maté-Muñoz, Eduardo Cuenca, Pablo García-Fernández, Fernando Mata-Ordoñez, María Carmen Lozano-Estevan, Pablo Veiga-Herreros, Sandro Fernandes da Silva, Manuel Vicente Garnacho-Castaño   +8 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Goal Content for the practice of physical activity and the impact on subjective well-being in older adults [PDF]

, 2018
The main goal of this study consisted in an analysis of the impact that the goal content that leads to the practice of physical activity in the elderly population can play on the variables that constitute subjective well-being, as well as to analyze the ...
Antunes, Raul, Cid, Luis, Couto, Nuno, Marinho, Daniel, Monteiro, Diogo, Moutão, João   +5 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Feasibility of a Novel School Peer-Led Mentoring Model to Improve the Physical Activity Levels and Sedentary Time of Adolescent Girls: The Girls Peer Activity (G-PACT) Project

Children, 2018
Regular physical activity (PA) is associated with numerous physical and psychological health benefits. Adolescents, specifically girls, are at risk of physical inactivity.
Michael B. Owen, Charlotte Kerner, Sarah L. Taylor, Robert J. Noonan, Lisa Newson, Maria-Christina Kosteli, Whitney B. Curry, Stuart J. Fairclough   +7 more
doaj   +1 more source

Associations between selected demographic, biological, school environmental and physical education based correlates, and adolescent physical activity

, 2011
The study investigated associations between selected physical activity correlates among 299 adolescents (90 boys, age 12-14 years) from 3 English schools. Physical activity was assessed by self-report and accelerometry. Correlates represented biological,
Fairclough, Stuart J., Hilland, Toni A., Ridgers, Nicola D., Stratton, Gareth   +3 more
core   +1 more source

Physical Activity Levels in Peripheral Artery Disease Patients [PDF]

, 2019
BACKGROUND: Increases in daily physical activity levels is recommended for patients with peripheral artery disease (PAD). However, despite this recommendation, little is known about the physical activity patterns of PAD patients.
Correia, Marilia de Almeida, Cucato, Gabriel, Domingues, Wagner Jorge Ribeiro, Gerage, Aline Mendes, Oliveira, Paulo Mesquita Longano de, Palmeira, Aline Cabral, Puech-Leão, Pedro, Ritti-Dias, Raphael Mendes, Wolosker, Nelson, Zeratti, Antônio Eduardo   +9 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Recall of physical activity advice was associated with higher levels of physical activity in colorectal cancer patients. [PDF]

, 2015
The present study tested the hypothesis that recall of receiving physical activity (PA) advice would be associated with higher levels of PA in patients with a diagnosis of colorectal cancer (CRC)
Beeken, R, Fisher, A, Wardle, J, Williams, K   +3 more
core   +1 more source