Results 81 to 90 of about 6,226,403 (313)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Association of life-space mobility with physical and depressive status in older hemodialysis patients: the REPnet-HD study

Renal Replacement Therapy
Introduction Low physical function and depressive symptoms are frequent in older patients undergoing hemodialysis. This study aimed to investigate the association between life-space mobility (LSM), low physical function, and depressive symptoms in older ...
Sho Kojima, Naoto Usui, Yuki Nishiyama, Nobuhito Shinozaki, Nobuyuki Shirai, Kenta Mikami, Yoichi Sato, Takahumi Noji, Izumi Noda, Yoshifumi Abe, Masakazu Saitoh   +10 more
doaj   +1 more source

Promoting children’s physical activity using adaptive playgrounds [PDF]

, 2006
This abstract introduces the innovative Playware playground and how it can be utilized for promoting children’s physical activity and thus partly addressing issues related to increasing obesity problems in the western society.
4th European Youth Heart Study Symposium : Children, Physical Activity & Health, Hammer, Frodi, Yannakakis, Georgios N.   +2 more
core  

The importance of both setting and intensity of physical activity in relation to non-clinical anxiety and depression [PDF]

, 2007
Physical activity is associated with good physical and mental health. Current recommendations suggest that people should achieve 30 minutes of moderate-intensity activity most days of the week to gain health benefits.
Bernaards C M, Biddle S JH, Biddle S JH, Camacho T C, Clark A, Cooper-Patrick L, Department of Health, Der G, Dong W, Dunn A, Dunn A L, Ecob R, Farmer M, Goldberg D P, Kearney J M, Kritz-Silverstein D, Lawlor D A, Lawlor D A, Macintyre S, Mobily K E, Moses J, Moti R W, Mutrie N, OPCS, Paffenbarger R S, Pate R R, Schnohr P, Seligman M EP, Snaith R P, Strawbridge W J, Thorsen L, US Department of Health and Human Services, Van Gool C H, Weyerer S, World Health Organisation   +34 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Impact of the Eduball method on cognitive creativity, motor creativity, and motor fitness during physical education classes in 8- to 9-year-old children

Frontiers in Public Health
IntroductionCreativity is increasingly recognized as a crucial skill across various fields. Although schools are placing more emphasis on fostering creativity, physical education (PE) often remains overlooked.
Maryna Khorkova, Łukasz Bojkowski, Agata Korcz, Jana Krzysztoszek, Marlena Łopatka, Dagny Adamczak, Michał Bronikowski   +6 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Age-related differences in exercise and quality of life among breast cancer survivors [PDF]

, 2010
Purpose: Physical activity has become a focus of cancer recovery research as it has the potential to reduce treatment-related burden and optimize health-related quality of life (HRQoL).
Arndt, BETH NEWMAN, Brady, Brucker, Connell, Coster, Courneya, Courneya, Daley, Di Sipio, Drouin, Hayes, Hayes, Holick, Holmes, Kelsey, Kimsey, King, Kopelman, McNeely, McPherson, Meyerhardt, Milne, Mock, Mutrie, Pinto, Pinto, SANDRA C. HAYES, Schmitz, Schwartz, SHEREE A. HARRISON, Stevinson, Thewes, van Dam, Wenzel   +34 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effectiveness of Intervention Strategies to Increase Adolescents’ Physical Activity and Reduce Sedentary Time in Secondary School Settings, Including Factors Related to Implementation: A Systematic Review and Meta-Analysis

Sports Medicine - Open
Background Globally, just one in five adolescents meet physical activity guidelines and three-quarters of the school day is spent sitting. It is unclear which types of school-based interventions strategies increase physical activity and reduce sedentary ...
Ana María Contardo Ayala, Kate Parker, Emiliano Mazzoli, Natalie Lander, Nicola D. Ridgers, Anna Timperio, David R. Lubans, Gavin Abbott, Harriet Koorts, Jo Salmon   +9 more
doaj   +1 more source