Results 51 to 60 of about 363,634 (266)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Influence of mean value of the modulus of elasticity in compression parallel to the grain on the design of timber trusses

Acta Scientiarum: Technology, 2022
The Brazilian standard ABNT NBR 7190 (Associação Brasileira de Normas Técnicas [ABNT], 1997) recommends adopting the mean value of the modulus of elasticity to compression in the direction parallel to the grain (Ec0,m) in the calculation of ...
Arthur Filipe Freire Gomes , Fernando Menezes de Almeida Filho, Júlio Cesar Molina, Fernando Júnior Resende Mascarenhas, Francisco Antônio Rocco Lahr, André Luis Christoforo   +5 more
doaj   +1 more source

Physical and Mechanical Properties of Rocks

, 2010
Since early antiquity dimension stones have been used as building materials due to their natural beauty and availability, and the diversity of their applications has increased ever since. As any other building material, dimension stones today have to fulfill the physical and technical requirements demanded by architects.
Siegesmund, Siegfried, Dürrast, Helmut, Siegesmund, Siegfried, Snethlage, R.   +3 more
openaire   +2 more sources

Physical And Mechanical Properties Of Sea Ice In Bending [PDF]

KnE Materials Science, 2016
<p>The work presents the study of changes in the physical and mechanical properties of sea ice in bending. Strength limit σ_в and deformation module Е_в of ice under bending are conditional mechanical characteristics of sea ice.
Koshkin, S. V., Taranukha, N. A.
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Ultrasonic evaluation of the physical and mechanical properties of granites [PDF]

Ultrasonics, 2008
Masonry is the oldest building material that survived until today, being used all over the world and being present in the most impressive historical structures as an evidence of spirit of enterprise of ancient cultures. Conservation, rehabilitation and strengthening of the built heritage and protection of human lives are clear demands of modern ...
Vasconcelos, Graça, Lourenço, Paulo B., Alves, C. A. S., Pamplona, J.   +3 more
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Investigation of the Utilization Impact of Alnus subcordata Waste and Poplar Wood in Particle Board Production [PDF]

تحقیقات علوم چوب و کاغذ ایران, 2015
In this study, the effect of using waste of Alnus subcordata and Poplar wood in manufacturing particle board was investigated. The particle boards were produced by adding (0-25-50-75-100)% alder branches with poplar wood and two press temperatures 170°C ...
Ardlan Doreemam, Vahidreza Safdari, Abolfazl Kargarfard, Ajang Tajdini   +3 more
doaj   +1 more source