Results 71 to 80 of about 187,963 (288)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Ultrasonic evaluation of the physical and mechanical properties of granites [PDF]

Ultrasonics, 2008
Masonry is the oldest building material that survived until today, being used all over the world and being present in the most impressive historical structures as an evidence of spirit of enterprise of ancient cultures. Conservation, rehabilitation and strengthening of the built heritage and protection of human lives are clear demands of modern ...
Vasconcelos, Graça, Lourenço, Paulo B., Alves, C. A. S., Pamplona, J.   +3 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Constitutive modelling and mechanical characterization of aluminium-based metal matrix composites produced by spark plasma sintering [PDF]

, 2010
Spark plasma sintering has been applied to the production of aluminium-based functionally graded material systems to be used in abrasive and high temperature conditions.
Estournès, Claude, C. Estournes, Bolzon, Gabriella, Egizabal, Pedro, E. J. Chiarullo, Chiarullo, Enzo J., P. Egizabal   +6 more
core   +1 more source

"Properties of solution polymerized styrene-butadiene rubber/silica composites modified by epoxidized solution polymerized styrene-butadiene rubber"

Hecheng xiangjiao gongye
The effect of epoxidized solution polymerized styrene-butadiene rubber (SSBR) with an epoxy degree of 15% on the processing properties, silica dispersion, physical and mechanical properties, and dynamic mechanical properties of SSBR/silica composite was ...
XIAO Tong-chang1, LI Xiang-yu1, QU Xiao2, DU Ai-hua1
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Reduction of refining energy during mechanical pulping [PDF]

, 2011
The effects of pressurised compressive chip pre-treatment and low dosage sulphite pre-treatment were evaluated for production of thermomechanical pulp in mill scale trials using Norway spruce (Picea abies) at the Braviken paper mill (Holmen Paper AB ...
Nelsson, Erik
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source