Results 51 to 60 of about 165,136 (217)

The stability of polysiloxanes incorporating nano-scale physical property modifiers

Science and Technology of Advanced Materials, 2008
Reported here is the synthesis and subsequent characterization of the physical and chemical properties of novel polysiloxane elastomers modified with a series of polyhedraloligomericsilsequioxane (POSS) molecular silicas.
James P Lewicki et al
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

"Properties of solution polymerized styrene-butadiene rubber/silica composites modified by epoxidized solution polymerized styrene-butadiene rubber"

Hecheng xiangjiao gongye
The effect of epoxidized solution polymerized styrene-butadiene rubber (SSBR) with an epoxy degree of 15% on the processing properties, silica dispersion, physical and mechanical properties, and dynamic mechanical properties of SSBR/silica composite was ...
XIAO Tong-chang1, LI Xiang-yu1, QU Xiao2, DU Ai-hua1
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Physical and Mechanical Properties of Fly Ash-Bottom Ash Geopolymer Mixtures on Expansive Clay Soil Stabilization as a Subgrade Material

Civil and Environmental Engineering
The presence of expansive clay causes roads to undergo damage such as wavy, cracked, and even potholes. This type of soil shows that the soil is prone to swelling and shrinking. A base soil handling method against the effects of swelling and shrinking is
Wijaya Miguel Felix, Ismanti Sito, Satyarno Iman   +2 more
doaj   +1 more source

Application of neodymium butadiene rubber BR 9101 N in the formula of support compound of run-flat tire

Hecheng xiangjiao gongye
The application of neodymium based cis-1,4-polybutadiene rubber (Nd-BR) BR 9101 N in the formula of support compound of run-flat tire was studied, and compared with those of foreign same type product Nd-BR CB 24.
XU Kai, XIE Xiao-hou, WANG Ai-sheng, CHEN Jian-jun
doaj   +1 more source