Results 31 to 40 of about 312,703 (216)
Practical Guide of Key Physical Considerations in Numerical Analysis for Nanophotonic Experiments
IEEE Photonics JournalInterest in the ever-expanding field of nanoscopy techniques has greatly increased in recent years. Specifically, in-depth characterization through optical techniques capable of nano-resolution enables a deep understanding of nanostructures and their ...
Avi Karsenty +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Special Theory of Relativity without special assumptions and tachyonic motion
Condensed Matter Physics, 2010 The most general form of transformations of space-time coordinates in Special Theory of Relativity based solely on physical assumptions is described. Only the linearity of space-time transformations and the constancy of the speed of light are used as ...
E. Kapuścik
doaj +1 more source
A class of symmetric-hyperbolic PDEs modelling fluid and solid continua*** [PDF]
ESAIM: Proceedings and SurveysWe generalize a new symmetric-hyperbolic system of PDEs proposed in [ESAIM:M2AN 55 (2021) 807-831] for Maxwell fluids to a class of systems that define unequivocally multi-dimensional visco-elastic flows. Precisely, within a general setting for continuum
Boyaval Sébastien
doaj +1 more source
Evaluating the economic impact of water scarcity in a changing world
Nature Communications, 2021 The impacts of water scarcity depend on physical basin characteristics and global economic dynamics. Here, the authors show scenario assumptions can yield either highly positive or negative economic impacts due to water scarcity, and the drivers of these
Flannery Dolan +5 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
FIGHTING THE CLASSICAL CRIME-SCENE ASSUMPTIONS. CRITICAL ASPECTS IN ESTABLISHING THE CRIME-SCENE PERIMETER IN COMPUTER-BASED EVIDENCE CASES [PDF]
Challenges of the Knowledge Society, 2016 Physical-world forensic investigation has the luxury of being tied to the sciences governing the investigated space, hence some assumptions can be made with some degree of certainty when investigating a crime.
Cristina DRIGĂ, Svetlana PURICI
doaj