Results 91 to 100 of about 1,915,001 (343)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Synthesis and Structural and Electrochemical Characterization of Carbon Fiber/MnO₂ Composites for Hydrogen Storage and Electrochemical Sensing

Fibers
Hydrogen, as an alternative energy carrier, presents significant prospects for the transition to more environmentally friendly energy solutions. However, its efficient and safe storage remains a challenge, as materials with high adsorbent capacity and ...
Loukia Plakia, Adamantia Zourou, Maria Zografaki, Evangelia Vouvoudi, Dimitrios Gavril, Konstantinos V. Kordatos, Nikos G. Tsierkezos, Ioannis Kartsonakis   +7 more
doaj   +1 more source

Spectral line survey of the ultracompact HII region Mon R2

, 2012
Ultracompact (UC) HII regions constitute one of the earliest phases in the formation of a massive star and are characterized by extreme physical conditions (Go>10^5 Habing field and n>10^6 cm^-3).
A. Fuente, Avery, Bachiller, Bayet, Berné, C. Joblin, C. Kramer, Caselli, Cernicharo, Cernicharo, Choi, Churchwell, D. Ginard, Daniel, Dayou, Flower, Fuente, Fuente, Fuente, Fuente, Fuente, García-Burillo, Gerin, Gerin, Gerin, Giannakopoulou, Goicoechea, Goicoechea, Goicoechea, Green, Guzmán, Henning, Herbst, J. Cernicharo, J. Pety, J. R. Goicoechea, J. R. Rizzo, Le Petit, Lique, Lique, Lucas, M. Gerin, M. González-García, Massi, Meyers-Rice, Monteiro, O. Berné, Ohishi, P. Pilleri, Parise, Parise, Parise, Pety, Pety, Rizzo, Rizzo, Roueff, S. García-Burillo, Sarrasin, Savage, Schenewerk, Schilke, Schloerb, Snyder, Sutton, T. Alonso-Albi, Tafalla, Tafalla, Teyssier, Turner, V. Ossenkopf, van der Wiel, Wernli, Wood, Yang   +74 more
core   +4 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Insights into the Carbon chemistry of Mon R2

, 2005
Aiming to learn about the chemistry of the dense PDR around the ultracompact (UC) HII region in Mon R2, we have observed a series of mm-wavelength transitions of C3H2 and C2H. In addition, we have traced the distribution of other molecules, such as H13CO+
A. Fuente, Chandra S., Fuente A., Garcia-Burillo S., Henning T., J. R. Rizzo, Le Bourlot J., Massi M., Rodriguez-Franco A., S. Garcia‐Burillo, Truong-Bach, Walmsley C. M.   +11 more
core   +3 more sources

EPR SPECTROSCOPY OF RUBY IN THE UNDERGRADUATE PHYSICAL CHEMISTRY TEACHING LABORATORY

, 2021
Bryan Lynch
openalex   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source