Results 71 to 80 of about 38,082 (273)

When Silence Breaks: The Influence of Pure Tones and White Noises on Conditioned Flight Responses

Brain and Behavior
Background The flight response is part of the repertoire of adaptive behavioral responses all animals possess and use to face threats coming from their environment.
Sebastiano Francesco Matarazzo di Licosa, Andrea Stefano Moro, Mattia Ferro, Antonio Malgaroli, Jacopo Lamanna   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Determining and testing the optimal pure-tone frequency for use in acoustic conditioning of free-ranging common carp (Cyprinus carpio)

, 2012
Pure-tone frequencies of 400, 700, and 1000 Hz were tested to determine which achieved the strongest response when used in conditioning experiments on captive common carp (Cyprinus carpio) for the purpose of determining the most effective frequency to ...
Mahoney, Brennan Andrew
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Quantitative analysis of the classical eyeblink conditioning test carried out with the four experimental groups.

, 2013
(A) Animals (n = 10 per group) were implanted with electromyographic (EMG) recording electrodes in the left orbicularis oculi (O.O.) muscle and with stimulating electrodes on the ipsilateral supraorbital nerve.
Noelia Madroñal (257880), José M. Delgado-García (106121), Cristina López-Aracil (364050), Alejandra Rangel (257878), José A. del Río (364051), Agnès Gruart (106156)   +5 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effects of Exercise on Cartilage Thickness and Chondrocytes Count: A Meta-Analysis of Pre-Clinical Randomized Controlled Trials Conducted on Rats

Allied Medical Research Journal
Background: The evidence regarding the effects of exercises on cartilage is enormous, but the literature on improving cartilage thickness and chondrocytes number is limited.
Kiran Yameen, Dr. Kevin Joseph Jerome Borges, Dr. Amna Aamir Khan, Dr. Syed Nudrat Nawaid Shah   +3 more
doaj  

Morfologia e contratilidade em cardiomiócitos de ratos com baixo desempenho para o exercício físico Morphology and contractility in cardiomyocytes of rats with low exercise performance

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A capacidade aeróbica é fundamental para o desempenho físico, e a baixa capacidade aeróbica está relacionada ao desencadeamento de diversas doenças cardiovasculares.
Judson Fonseca Quintão Júnior, Antônio José Natali, Miguel Araújo Carneiro Júnior, Cynthia Aparecida de Castro, Lucas Rios Drummond, Victor Neiva Lavorato, Leonardo Bonato Felix, Jader dos Santos Cruz, Thales Nicolau Prímola-Gomes   +8 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source