Results 11 to 20 of about 575 (106)

Absolute Number of Thalamic Parafascicular and Striatal Cholinergic Neurons, and the Three-Dimensional Spatial Array of Striatal Cholinergic Neurons, in the Sprague-Dawley Rat. [PDF]

J Comp Neurol
The absolute numbers of thalamic parafascicular (PFN) neurons and striatal cholinergic interneurons (CIN) were estimated in rats using unbiased stereological methods. Spatial statistical analysis of the three‐dimensional distribution revealed that the large, mostly CIN were randomly positioned with no evidence of clustering.
Zhang R, Wickens JR, Carrasco A, Oorschot DE.   +3 more
europepmc   +2 more sources

Automated Euler number of the alveolar capillary network based on deep learning segmentation with verification by stereological methods. [PDF]

J Microsc
Abstract Diseases like bronchopulmonary dysplasia (BPD) affect the development of the pulmonary vasculature, including the alveolar capillary network (ACN). Since pulmonary development is highly dependent on angiogenesis and microvascular maturation, ACN investigations are essential.
Schmidt J, Labode J, Wrede C, Regin Y, Toelen J, Mühlfeld C.   +5 more
europepmc   +2 more sources

Counting glomeruli in human kidney specimens using ex vivo MRI without contrast agents. [PDF]

Magn Reson Med
Abstract Purpose The total number of glomeruli is an important indicator of kidney function and susceptibility to disease. Glomeruli, however, are difficult to image using MRI without contrast enhancement. For this reason, previous studies have used cationic ferritin as a contrast agent to detect glomeruli in ex vivo and in vivo perfused kidneys.
Kurniawan ND, Amar AJ, Cullen-McEwen LA, Combes AN, Hayatudin R, Kassianos AJ, Du J, Gazzard SE, Healy HG, Hoy WE, Bertram JF, Reutens DC.   +11 more
europepmc   +2 more sources

Basic quantitative morphological methods applied to the central nervous system. [PDF]

J Comp Neurol, 2021
Design‐based stereological methods allow the estimation of basic morphological parameters in representative samples of the sectioned central nervous system. Point probes can be used to estimate volume (illustrated for the Area Fraction Fractionator), line probes can be used to estimate surface area (illustrated for a vertical sections design), area ...
Slomianka L.
europepmc   +2 more sources

Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice. [PDF]

J Anat, 2023
Aging was associated with hypertrophy of left venticular myocardium in mice without an increase in mitochondrial number. Spermidine treatment increased the number of cardiomyocyte mitochondria significantly. The three‐dimensional ultrastructure of mitochondria showed signs of disarrangement in aged mice which was reduced by spermidine treatment ...
Messerer J, Wrede C, Schipke J, Brandenberger C, Abdellatif M, Eisenberg T, Madeo F, Sedej S, Mühlfeld C.   +8 more
europepmc   +2 more sources

Investigating Neotenic and Metamorphic Axolotl Brain Complexity: A Stereological and Immunohistochemical Perspective. [PDF]

J Comp Neurol
In the telencephalon, apical specializations such as cilia, primary cilia, and microvilli with varying morphologies were observed. Goblet‐like cells, arranged in a single row along the ventricular wall, contained secretory vesicles in their apical regions. Light microscopy demonstrated that these secretory vesicles had a carbohydrate‐rich structure, as
Kaplan AA, Öztürk G, Bay S, Keskin İ.
europepmc   +2 more sources

A reassessment of spinal cord pathology in severe infantile spinal muscular atrophy: Reassessment of spinal cord pathology. [PDF]

Neuropathol Appl Neurobiol
Spinal cord pathology in severe spinal muscular atrophy patients is more widespread than originally described. Motor neuron loss is substantial, remaining ventral horn neurons, and Clarke's column neurons are abnormal but lateral horn neurons are preserved. Grey and white matter and the gross dimensions of the spinal cord are all affected.
Allardyce H, Lawrence BD, Crawford TO, Sumner CJ, Parson SH.   +4 more
europepmc   +2 more sources

Nephron deficit and low podocyte density increase risk of albuminuria and glomerulosclerosis in a model of diabetes

Physiological Reports, Volume 11, Issue 2, January 2023., 2023
This study examined whether a suboptimal maternal environment (maternal low protein diet) would result in low podocyte endowment and increase the risk of diabetes‐induced renal injury. The present findings demonstrate that a permanent nephron deficit combined with a postnatal hyperglycemic challenge can increase the risk of albuminuria and ...
Sarah E. Gazzard, James van der Wolde, Kotaro Haruhara, John F. Bertram, Luise A. Cullen‐McEwen   +4 more
wiley   +1 more source

Plasticity of the spinal glymphatic system in male SD rats with painful diabetic neuropathy induced by type 2 diabetes mellitus

Journal of Neuroscience Research, Volume 100, Issue 10, Page 1908-1920, October 2022., 2022
The activity of spinal glymphatic system of rats with painful diabetic neuropathy was inhibited, and our results indicated that the increased number of GFAP positive astrocytes and aquaporin‐4 polarity reversal may worked as its mechanism. Abstract The glymphatic system is a recently discovered glial‐dependent macroscopic interstitial waste clearance ...
Guo‐Qiang Wang, Fei‐Xiang Wang, Yi‐Na He, Jing‐Yan Lin   +3 more
wiley   +1 more source

COVID‐19 Infection Enhances Susceptibility to Oxidative Stress–Induced Parkinsonism

Movement Disorders, Volume 37, Issue 7, Page 1394-1404, July 2022., 2022
July Infographic : COVID‐19 Infection Enhances Susceptibility to Oxidative Stress–Induced Parkinsonism ABSTRACT Background Viral induction of neurological syndromes has been a concern since parkinsonian‐like features were observed in patients diagnosed with encephalitis lethargica subsequent to the 1918 influenza pandemic. Given the similarities in the
Richard J. Smeyne, Jeffrey B. Eells, Debotri Chatterjee, Matthew Byrne, Shaw M. Akula, Srinivas Sriramula, Dorcas P. O'Rourke, Peter Schmidt   +7 more
wiley   +1 more source