Results 41 to 50 of about 12,608 (247)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Pre-germination treatments on Ochetophila trinervis, a native Andean tree with potential use for restoration

Revista de la Facultad de Ciencias Agrarias, 2022
In a climate change scenario, global forest loss had a direct impact on the hydrological cycle, making the protection of soil and water resources a central issue. In the Central Andes of western Argentina, information on Chacay (Ochetophila trinervis)
Leandro Manuel Alvarez, Cecilia Vega Riveros, Pablo Eugenio Villagra   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

First Report of Viviparity in Seeds of the Physically Dormant Species Hymenaea martiana (Fabaceae)

Seeds
Viviparity is rarely reported in species with seed physical dormancy. This is because physical dormancy, common in tropical trees, results from the impermeability of the seed tegument to water and regulates the timing of germination.
Joyce Naiara da Silva, Guilherme Vinícius Gonçalves de Pádua, Caroline Marques Rodrigues, Eduardo Luã Fernandes da Silva, Aline das Graças Souza, Edna Ursulino Alves   +5 more
doaj   +1 more source

Is there physical dormancy Psidium cattleianum Sabine seeds?

, 2022
The objective of this research was to evaluate the presence of physical dormancy in seeds of Psidium cattleianum (araçá), obtained from fruits of different stages of maturation. The fruits were collected from 15 parent plants in the municipality of Lages-SC and classified, according to the Munsell color chart, in yellowish red (5YR5 / 7), red (10R5 / 6)
Lopes, Betel Cavalcante, Sá, Alexandra Cristina, Corrêa, Bruno Jan, Dambros, Vanessa Giseli, Oliveira, Luciana Magda de   +4 more
openaire   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Physical seed dormancy in native legume species of Argentina

, 2016
Fil: Ortega Baes, Francisco Pablo. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Laboratorio de Investigaciones Botánicas; Argentina.
Galindez, Guadalupe, Ceccato, Diana, Malagrina, Gisela, Pidal, Barbara, Chilo, Gladys, Bach, Hernán Gerónimo, Fortunato, Renée Hersilia, Ortega Baes, Francisco Pablo   +7 more
openaire   +3 more sources

Physical and chemical methods to breach seed dormancy of sugar apple

Revista de Ciências Agrarias - Amazon Journal of Agricultural and Environmental Sciences, 2013
Cultivation of sugar apple has increased in the Setentrional Amazon, but one of the problems for obtaining quality seedlings is related to overcoming dormancy of its seeds. The objective of the present study was to evaluate the efficiency of physical and chemical methods to break sugar apple seed dormancy.
Chagas, Pollyana Cardoso, Sobra, Sara Thiele Moreira, Oliveira, Railin Rodrigues de, Chagas, Edvan Alves, Pio, Rafael, Santos, Verônica Andrade dos   +5 more
openaire   +2 more sources

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source