Results 71 to 80 of about 9,890,145 (379)

Multimodal neuroimaging insights into central mechanisms of overactive bladder with an empty bladder: a cross-sectional study

European Journal of Medical Research
Background and objective Overactive bladder (OAB) is a complex condition involving central nervous system (CNS) processes that are not fully understood.
Yangkun Feng, Yuwei Zhang, Ju Zhang, Yifan Sun, Deshui Yu, Huihui Song, Kaixin Zhang, Feng Lu, Xi Liu, Xiuhong Hua, Siyi Fu, Jia Xu, Yi Fan, Jianfeng Shao, Ye Hua   +14 more
doaj   +1 more source

Nonlinear relationship with saturation effect observed between neutrophil to high-density lipoprotein cholesterol ratio and atherosclerosis in a health examination population: a cross‐sectional study

BMC Cardiovascular Disorders, 2022
Background The relationships between inflammatory indexes and atherosclerosis as well as those between blood lipid indexes and atherosclerosis have been widely studied, but the relationship between the neutrophil to high-density lipoprotein cholesterol ...
Yaqing Zhou, Haijun Dan, Long Bai, Limei Jia, Baojin Lu, Wei Cui   +5 more
doaj   +1 more source

Cortisol Secreting Adrenal Adenoma in a 5 Year Old Child [PDF]

, 2011
Adrenal adenoma is a rare endocrinal tumor in children. It can present with features of Cushing's syndrome. We present a case report of five years old female child who came with morbid obesity and hypertension.
Narang, Gursharan Singh, Pahwa, Jivtesh Singh   +1 more
core  

Transcending Big Bang in Loop Quantum Cosmology: Recent Advances [PDF]

, 2008
We discuss the way non-perturbative quantization of cosmological spacetimes in loop quantum cosmology provides insights on the physics of Planck scale and the resolution of big bang singularity.
Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Banerjee K, Bianchi E, Bojowald M, Bojowald M, Corichi A, Corichi A, Corichi A, Dadhich N, Date G, Freidel L, Mielczarek J, Parampreet Singh, Szulc L, Thiemann T, Zhang X   +20 more
core   +3 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

CircHIPK3/miR-876-5p/PIK3R1 axis regulates regulation proliferation, migration, invasion, and glutaminolysis in gastric cancer cells

Cancer Cell International, 2020
Background Circular RNAs (circRNAs) are a new group of non-coding RNAs that play vital roles in cancer occurrence, including gastric cancer (GC). Nevertheless, the role and underlying regulatory mechanisms of circHIPK3 in GC remain unclear.
Qingchun Li, Yuan Tian, Yun Liang, Chang Li   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The relationship between perceived stress and job burnout of police officers during the COVID-19 pandemic: the mediating role of social support, sleep quality and resilience

BMC Public Health
Background With the rapid spread of Corona Virus Disease 2019 (COVID-19) in China, police officers were undergoing higher job stress, which made them physically and mentally exhausted, eventually leading to job burnout.
Xuyu Chen, Yi Xu, Qi Zhang, Hongwei Huang, Xiaodong Tan, Yang Yang   +5 more
doaj   +1 more source

Physical Examination and Patellofemoral Pain Syndrome: an Updated Review

Current Reviews in Musculoskeletal Medicine, 2021
Donald Kasitinon, Wei-Xian Li, Eric Wang, M. Fredericson   +3 more
semanticscholar   +1 more source