Results 71 to 80 of about 8,303,866 (364)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Osteosarcopenic obesity and its components—osteoporosis, sarcopenia, and obesity—are associated with blood cell count-derived inflammation indices in older Chinese people

BMC Geriatrics, 2022
Background The aim of this study was to investigate the associations of osteosarcopenic obesity (OSO) and its components with complete blood cell count-derived inflammation indices. Methods In this cross-sectional study, data of 648 participants aged ≥60 
Yi-zhen Nie, Zhao-qi Yan, Hui Yin, Ling-han Shan, Jia-hui Wang, Qun-hong Wu   +5 more
doaj   +1 more source

Unambiguous Discrimination Between Linearly-Independent Quantum States [PDF]

Phys.Lett. A239 (1998) 339-347, 1998
The theory of generalised measurements is used to examine the problem of discriminating unambiguously between non-orthogonal pure quantum states. Measurements of this type never give erroneous results, although, in general, there will be a non-zero probability of a result being inconclusive.
arxiv   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Importance Of Thorough Physical Examination: A Lost Art

Cureus, 2017
Several recent studies have described a deterioration in physical examination skills among modern physicians. Reasons hypothesized for this change are improvements in technology and time constraints.
Talal Asif, A. Mohiuddin, Badar Hasan, R. Pauly   +3 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data

Frontiers in Pharmacology
BackgroundMedroxyprogesterone acetate (MPA), a synthetic progestogen, is extensively used for the treatment of various conditions, including contraception, irregular menstruation, functional uterine bleeding, and endometriosis.
Luyang Su, Ren Xu, Yanan Ren, Shixia Zhao, Weilan Liu, Zeqing Du   +5 more
doaj   +1 more source

Neurological examination in the healthy term newborn [PDF]

Arquivos de Neuro-Psiquiatria, 2003
We carried out a cross-sectional study with a sample of 106 normal full-term newborns examined within 24 to 72 hours of birth. The following findings were evaluated: head and chest measurements, muscle strength, tone, tendon reflexes, superficial ...
Fleming S. Pedroso, Newra T. Rotta
doaj   +1 more source

History and physical examination

Best Practice & Research Clinical Rheumatology, 2003
Musculoskeletal conditions are common, their impact is pervasive and they are a major burden on health and social care. However, they are poorly managed because of lack of priority and inadequate competencies due to limited medical education in this spectrum of conditions. The ability to take a clear history and perform a competent examination are core
openaire   +3 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source