Results 91 to 100 of about 5,156,216 (304)
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
BMC Musculoskeletal Disorders, 2012 Background The prevalence of musculoskeletal pain is high among healthcare workers. Knowledge about risk factors at work is needed to efficiently target preventive strategies. This study estimates the prognosis for recovery from long-term musculoskeletal
Andersen Lars L +3 more
doaj +1 more source
Designing for Social and Physical Interaction in Exertion Games [PDF]
, 2014 Exertion games lend themselves to facilitating social and physical interactions, in particular when compared to button-press games. However, there is little understanding of how specific aspects of an exertion game’s design can facilitate these social and physical interactions.
Florian 'Floyd' Mueller +2 more
openaire +2 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
BMJ Open Sport & Exercise MedicineBackground Assessment of recovery from mild traumatic brain injury (mTBI) is complex and challenging. Post-exertion testing, where individuals undergo objective testing following physical exercise, has shown promise in identifying mTBI-related ...
Duncan Reid +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
FEBS Open Bio, EarlyView.Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji +3 more
wiley +1 more source
Weight issues during submarine deployments
Journal of Marine Medical Society, 2015 Physical activity onboard the diesel-electric submarines is as it is restricted due to lack of space onboard. In the absence of physical activity, one would expect the weight of the submarine crew to increase during the period of deployment at sea ...
Sourabh Bhutani +3 more
doaj +1 more source
On repulsive gravitational actions [PDF]
arXiv, 2007 In particular instances and in particular regions the Einsteinian gravity exerts a repulsive action -- and without any cosmological term. This fact could have an interest for the explanation of the dark energy, and for the gravitational collapses.
arxiv