Results 71 to 80 of about 215,358 (303)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Physical exertion and triggering of myocardial infarction [PDF]

European Heart Journal, 2008
Physical exertion and triggering of myocardial infarction.
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Perceived physical exertion during healthcare work and prognosis for recovery from long-term pain in different body regions: Prospective cohort study

BMC Musculoskeletal Disorders, 2012
Background The prevalence of musculoskeletal pain is high among healthcare workers. Knowledge about risk factors at work is needed to efficiently target preventive strategies. This study estimates the prognosis for recovery from long-term musculoskeletal
Andersen Lars L, Clausen Thomas, Persson Roger, Holtermann Andreas   +3 more
doaj   +1 more source

Reliability and Validity of Ratings of Perceived Exertion in Persons With Multiple Sclerosis [PDF]

, 2016
Objective: To test the reliability and validity of using the Borg rating of perceived exertion (RPE) scale (ratings 6e20) in persons with multiple sclerosis (PwMS). Design: Nonrandomized repeated measures. Setting: Research laboratory.
Cleland, Brice T., Ingraham, Benjamin A., Ng, Alexander V., Pitluck, Molly C.   +3 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The reproducibility of perceptually regulated exercise responses during short-term cycle ergometry [PDF]

, 2004
This is the author's PDF version of an article published in International journal of sports medicine in 2004. The definitive version is available at www.thieme-connect.com.The purpose of this study was to assess the reproducibility over four trials of ...
Hartshorn, James E. O., Lamb, Kevin L.
core   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Obesity as a noticeable cause of physical stress; A study on relationship of physical exertion and cardiovascular parameters

International Journal of Endorsing Health Science Research, 2016
Introduction Physical tension is a response to environmental pressures, needs or demands or any vigorous bodily activity leading in altering physiological responses, is counted as physical stress such as aerobics, work outs, injury or aches.
Ammara Farooq, Muzna Patel, Sadaf Ahmed, Shamoon Noushad   +3 more
doaj   +1 more source