Results 61 to 70 of about 5,970,793 (286)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Cerebral carbohydrate cost of physical exertion in humans [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2004
Above a certain level of cerebral activation the brain increases its uptake of glucose more than that of O2, i.e., the cerebral metabolic ratio of O2/(glucose + [Formula: see text] lactate) decreases. This study quantified such surplus brain uptake of carbohydrate relative to O2 in eight healthy males who performed exhaustive exercise.
Dalsgaard, Mads K, Ogoh, Shigehiko, Dawson, Ellen A, Yoshiga, Chie C, Quistorff, Bjørn, Secher, Niels H   +5 more
openaire   +3 more sources

Preregistration, datasets and analyses for "The impact of cognitive and physical effort exertion on physical effort decisions: A pilot experiment"

, 2022
Research suggests that cognitive fatigue has a negative impact on physical activity participation. However, the mechanisms underlying this effect are yet unclear.
Husain, M., Geurts, S.A.E., Beckers, D.G.J., As, S. van, Kompier, M.A.J., Veling, H.P., Sabine Geurts, Michiel A. J. Kompier, Harm Veling, Masud Husain, Debby G. J. Beckers, Sven van As   +11 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Reduced Inhibitory Control Under Effortful Physical Exertion During Dual-Task Conditions [PDF]

, 2023
Physical action and cognition are often entangled in our daily lives. To understand the impact of effortful physical action on cognition, the work presented in this dissertation used a simple, yet effortful, physical action (i.e., effortful handgrip ...
Azer, Lilian
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Comparison of different ways of expressing creatine kinase concentration of soccer players during a competitive season

Motriz: Revista de Educacao Fisica
The aim of this study was to analyze the responses of creatine kinase [CK] expressed in different forms to the training load of professional soccer players during a competitive season. Twelve players (age, 24 ± 4 years) participated in the study.
Daniel Barbosa Coelho, Christian Emmanuel Torres Cabido, Victor Augusto Lemos Ciminelli, Leonardo Gomes Martins Coelho, Lenice Kapes Becker, Emerson Cruz de Oliveira, Emerson Rodrigues Pereira, João Carlos Bouzas Marins, Emerson Silami Garcia   +8 more
doaj   +1 more source

Skin temperature of middle distance runners after a maximum effort test

Acta Scientiarum. Health Sciences, 2020
The purpose of this study was to analyze skin temperature (Tsk) responses after a short-term maximum effort test in middle-distance runners. A quasi-experimental study was conducted with ten men (age 23.5±5.10 years) who trained 5 days per week, 2 to 3 ...
Jean Artur Mendonça Barboza, Larissa Isabelle Soares Souza, Mikhail Santos Cerqueira, Palloma Rodrigues de Andrade, Heleodório Honorato dos Santos, José Jamacy de Almeida Ferreira   +5 more
doaj   +1 more source

Factors affecting perceived exertion and task duration during intermittent isometric fatiguing exercise and their implications for rehabilitation following knee surgery [PDF]

, 2012
It has been theorised that self-perception is integral to the regulation of exercise and production of an optimal performance. This concept has not been examined in an anterior cruciate ligament (ACL) reconstructed population where the consequences of ...
Shepherd, J
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source