Results 81 to 90 of about 91,865 (295)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Skin temperature of middle distance runners after a maximum effort test

open access: yesActa Scientiarum. Health Sciences, 2020
The purpose of this study was to analyze skin temperature (Tsk) responses after a short-term maximum effort test in middle-distance runners. A quasi-experimental study was conducted with ten men (age 23.5±5.10 years) who trained 5 days per week, 2 to 3 ...
Jean Artur Mendonça Barboza   +5 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Effect of varied music applications in cycle ergometry [PDF]

open access: yes, 2012
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityThe aim of this research programme was to investigate the effects of different music applications: The differentiated exposure of music and the ...
Lim Ban Teck, Harry
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Perceived physical exertion during healthcare work and prognosis for recovery from long-term pain in different body regions: Prospective cohort study

open access: yesBMC Musculoskeletal Disorders, 2012
Background The prevalence of musculoskeletal pain is high among healthcare workers. Knowledge about risk factors at work is needed to efficiently target preventive strategies. This study estimates the prognosis for recovery from long-term musculoskeletal
Andersen Lars L   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Results of multilevel modeling for perceived physical exertion (PE).

open access: yes, 2018
Results of multilevel modeling for perceived physical exertion (PE).
Aaron S. Dietz (5851361)   +10 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

Obesity as a noticeable cause of physical stress; A study on relationship of physical exertion and cardiovascular parameters

open access: yesInternational Journal of Endorsing Health Science Research, 2016
Introduction Physical tension is a response to environmental pressures, needs or demands or any vigorous bodily activity leading in altering physiological responses, is counted as physical stress such as aerobics, work outs, injury or aches.
Ammara Farooq   +3 more
doaj   +1 more source

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