Results 81 to 90 of about 2,296,541 (319)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Association of day length and weather conditions with physical activity levels in older community dwelling people [PDF]

, 2014
Background: Weather is a potentially important determinant of physical activity. Little work has been done examining the relationship between weather and physical activity, and potential modifiers of any relationship in older people. Wetherefore examined
McMurdo, Marion E. T., Falko F Sniehotta, Donnan, Peter T, Vadiveloo, Thenmalar, Miles D Witham, Crombie, Iain K, Witham, Miles D, Crombie, Iain K., McMurdo Marion E. T., Witham, Miles D., Donnan Peter T., Vadiveloo Thenmalar, Sniehotta Falko F., Sniehotta, Falko F., Donnan, Peter T.; id_orcid, Feng Zhiqiang, McMurdo, Marion E T, Iain K Crombie, Peter T Donnan, Crombie Iain K., Marion E T McMurdo, Thenmalar Vadiveloo, Feng, Zhiqiang, Sniehotta, Falko F, Zhiqiang Feng, Witham Miles D.   +25 more
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Cardiorespiratory and vascular function outcomes following 4 weeks of single-sprint training

Frontiers in Physiology
IntroductionIt is unknown if brief intense exercise bouts are sufficient to improve vascular function.MethodsHealthy participants (n=46) ages 18–35 were allocated to either a training (n=24) or control (n=22) group.
Matthew A. Chatlaong, Matthew A. Chatlaong, John P. Bentley, Hannah C. Dowell, Orlandria J. Smith, Matthew B. Jessee   +5 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Responsiveness and Interpretability of 2 Measures of Physical Function in Patients With Spondyloarthritis

, 2020
Background. Maintenance or improvement of physical function is an important treatment target in the management of patients with axial spondyloarthritis (axSpA); measurement tools that can detect changes in physical function are therefore important ...
Dagfinrud, H., Sveaas, Silje Halvorsen, Pedersen, E., Sveaas, S.H., Hagen, Kåre Birger, Fongen, C., Dagfinrud, Hanne, Fongen, Camilla, Johansen, M.W., Weely, S. van, Hagen, K.B., Johansen, Melissa Woll, Bilberg, A., Pedersen, Elisabeth, Bilberg, Annelie,, van Weely, Salima   +15 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

An evaluation of gastrocnemius muscle structure and function in endurance runners and low physical activity individuals

, 2013
Includes abstract.Includes bibliographical references.Distance running has become increasingly popular in recreational runners. The gastrocnemius is the main muscle used for propulsion in running, and may be at risk for injury due to its morphology.
Buchholtz, Kim
core