Results 101 to 110 of about 2,296,541 (319)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Skin microvascular reactivity in children and adolescents with type 1 diabetes in relation to levels of physical activity and aerobic fitness

, 2008
No studies to date have evaluated the relationship between exercise and microvascular function in youth with type 1 diabetes mellitus (T1DM). Twenty-nine complication free children and adolescents with T1DM were assessed for skin microvascular reactivity,
Cable, Tim, Roche, Denise, Stratton, Gareth, Roche, Denise M., Edmunds, Sarah, Didi, Mo   +5 more
core  

Quality of life is associated with physical activity and fitness in cystic fibrosis [PDF]

, 2014
BACKGROUND: Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials.
Helge Hebestreit, Schmid, K, Junge, Sibylle, Hebestreit, Helge Uwe, Hebestreit, H, Schindler, C, Schmid, Kerstin, Kriemler, Susi, Christian Schindler, Schenk, T, Hebestreit, Alexandra, Ballmann, Manfred, Hebestreit, A, Kerstin Schmid, Stephanie Kieser, Hans-Georg Posselt, Manfred Ballmann, Thomas Schenk, Roth, K, Schenk, Thomas, Junge, S, Posselt, H G, Posselt, Hans-Georg, Sibylle Junge, Alexandra Hebestreit, Kieser, Stephanie, Hebestreit, Helge, Ballmann, M, Susi Kriemler, Schindler, Christian, Roth, Kristina, Kristina Roth   +31 more
core   +1 more source

Evaluating GPT-4V’s performance in the Japanese national dental examination: A challenge explored

Journal of Dental Sciences
Background/purpose: Rapid advancements in AI technology have led to significant interest in its application across various fields, including medicine and dentistry.
Masaki Morishita, Hikaru Fukuda, Kosuke Muraoka, Taiji Nakamura, Masanari Hayashi, Izumi Yoshioka, Kentaro Ono, Shuji Awano   +7 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Pain extent and function in youth with physical disabilities

, 2017
Jordi Miró,1–4 Rocío de la Vega,1,5 Catarina Tomé-Pires,1–3 Elisabet Sánchez-Rodríguez,1–3 Elena Castarlenas,1–3 Mark P Jensen,5 Joyce M Engel,6 1Unit for the Study and Treatment of Pain &ndash ...
Jensen MP, de la Vega R, Miró J, Castarlenas E, Tomé-Pires C, Sánchez-Rodríguez E, Engel JM   +6 more
core  

White book on physical and rehabilitation medicine (PRM) in Europe. Chapter 8.The PRM specialty in the healthcare system and society

, 2018
In the context of the White Book of Physical and Rehabilitation Medicine (PRM) in Europe, this paper deals with a global overview of the role of PRM in healthcare systems in Europe.
Ceravolo Maria Gabriella, European Physical and Rehabilitation Medicine Bodies Alliance   +1 more
core   +1 more source

Physical function measures and health-related quality of life in primary care medicine: cross-sectional study [PDF]

, 2017
Background . Health-related quality of life (HRQoL) is an important component of comprehensive management in primary care. Objectives. The purpose of this study was to investigate the relationships between physical performance measures and self ...
Annika Aart, Kallikorm, Riina, Raili Müller, Ann Starkopf, Müller, Raili, Kaja Põlluste, Lember, Margus, Margus Lember, Mart Kull, Kull, Mart, Anu Starkopf, Aart, Annika, Starkopf, Ann, Riina Kallikorm, Põlluste, Kaja, Starkopf, Anu   +15 more
core   +1 more source